PMID: 9436728Jan 22, 1998Paper

Minor physical anomalies in familial and sporadic schizophrenia: the Maudsley family study

Journal of Neurology, Neurosurgery, and Psychiatry
T D GriffithsR M Murray

Abstract

(1) To test the hypothesis that minor physical anomalies are increased in patients with schizophrenia and (2) to investigate differences in the prevalence of minor physical anomalies in patients with familial and sporadic schizophrenia and their first degree relatives. A weighted Waldrop assessment was carried out on 214 subjects in five groups: schizophrenic patients from multiply affected families; first degree relatives of these familial schizophrenic patients; sporadic schizophrenic patients; first degree relatives of these sporadic schizophrenic patients, and normal controls. Broad and narrow criteria for abnormality were defined based on the distribution of minor physical anomalies in the control group. (1) The total schizophrenic group did not have a significant increase in minor physical anomalies using a narrow criterion of abnormality, but did when a broader criterion was used. (2) A significant increase in the proportion of subjects with an abnormally high number of minor physical abnormalities was shown in the group of sporadic schizophrenic patients (uncorrected p<0.01). Separate analyses for males and females showed a significant increase in the male sporadic group (uncorrected p<0.05), and a smaller non-significa...Continue Reading

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Citations

Jan 23, 2002·American Journal of Medical Genetics·L E ScuttA S Bassett
Mar 17, 2000·Brain Research. Brain Research Reviews·T F McNeilB Ismail
Nov 14, 2001·Schizophrenia Research·M TrixlerR Szabó
Sep 6, 2003·Schizophrenia Research·T ToulopoulouR G Morris
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Bin XuMaria Karayiorgou
Feb 18, 2006·Journal of Clinical and Experimental Neuropsychology·Rachel WolitzkyDolores Malaspina
Oct 2, 2009·Schizophrenia Bulletin·Bruce I TuretskyPaul J Moberg
Mar 12, 2010·Psychiatry Research·Migdyrai Martín-ReyesMitchell Valdés Sosa
Jan 15, 2010·Psychiatry Research·Jadranka Culav-Sumić, Vlado Jukić
Feb 19, 2009·Schizophrenia Research·Allyssa J AllenGodfrey D Pearlson
Nov 3, 2006·Schizophrenia Research·Seth M WeinbergBrion S Maher
Oct 6, 1999·Biological Psychiatry·A S Bassett, E W Chow
Sep 15, 2004·Biological Psychiatry·Timothea ToulopoulouRobin M Murray
Aug 12, 2016·Psychiatry Research·Mehtap DeliceGamze Mandali
Apr 1, 2001·Multivariate Behavioral Research·S Rabe-HeskethR M Murray
Nov 11, 2003·American Journal of Medical Genetics. Part a·Johannes H M MerksRaoul C M Hennekam
Jun 28, 2006·Molecular Psychiatry·A Jablensky
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Nov 1, 2001·Expert Review of Neurotherapeutics·J Boydell
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Nov 1, 2010·International Journal of Psychiatry in Clinical Practice·Guillem Pailhez, Antonio Bulbena
Aug 9, 2019·Nordic Journal of Psychiatry·Konstantinos N FountoulakisIoannis Nimatoudis
Jul 30, 2021·Journal of Psychiatric Research·Vanteemar S SreerajUNKNOWN Accelerator Program for Discovery in Brain disorders using Stem cells (ADBS) Consortium

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