Minor Plasma Lipids Modulate Clotting Factor Activities and May Affect Thrombosis Risk.

Research and Practice in Thrombosis and Haemostasis
Hiroshi DeguchiJohn H Griffin

Abstract

Different minor abundance plasma lipids significantly influence thrombin generation in vitro and significant differences in such lipids are linked to risk for venous thrombosis. Some plasma sphingolipids including glucosylceramide, lyso-sulfatide and sphingosine have anticoagulant properties whereas, conversely, some plasma phospholipid derivatives, including certain lyso-phospholipids and ethanolamides, have procoagulant properties. Plasma metabolite profiling of venous thrombosis patients showed association of venous thrombosis with decreased plasma long-chain acylcarntines, leading to discovery of their anticoagulant activity as inhibitors of factor Xa. Inhibition of factor Xa by acylcarnitines does not require the protein's Gla-domain, emphasizing an expanded framework for the paradigm for lipid-clotting factor interactions. Overall, whether by genetics or environment, alterations in the dynamics of lipid metabolism linked to an altered lipidome may contribute to regulation of blood coagulation because imbalances between physiologic procoagulant and anticoagulant lipids may contribute to excessive thrombin generation that augments risk for thrombosis.

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Citations

Oct 15, 2018·Journal of Cellular Physiology·Edoardo EliaFederico Carbone
Feb 29, 2020·Research and Practice in Thrombosis and Haemostasis·José A FernándezJohn H Griffin
Jan 24, 2021·Cardiovascular Research·Wern Yew DingGregory Y H Lip
Feb 12, 2021·Progress in Lipid Research·Ilaria CasariMarco Falasca

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