Minor psychiatric disorders and objective diagnosis of gastroesophageal reflux disease

Surgical Endoscopy
Rafael Melillo Laurino NetoMarco G Patti

Abstract

Symptoms may be unreliable to diagnose gastroesophageal reflux disease (GERD) in patients with minor psychiatric disorders (MPD). This study aims to evaluate the influence of MPD in the diagnosis of GERD. We prospectively studied 245 patients (based on a sample size calculation) with suspected GERD. All patients underwent manometry and pH monitoring and MPD evaluation based on the Hospital Anxiety and Depression Scale (HADS). Based on the results of the pH monitoring, patients were classified as GERD + (n = 136, 55% of the total, mean age 46 years, 47% females) or GERD - (n = 109, 45% of the total, mean age 43 years, 60% females). The mean HADS score for GERD + and GERD - for anxiety was 7.8 and 8.5, respectively (p = 0.8) and for depression was 5.4 and 6.1, respectively (p = 0.1). DeMeester score (DS) did not correlate with total HADS score (p = 0.08) or depression domain (p = 0.9) but there was a negative correlation between DS and anxiety level (p < 0.001). A significant threshold accuracy value for HADS to diagnose GERD was not found on receiver operating characteristics curve analysis. Almost half of the patients evaluated for GERD did not have the disease on objective evaluation. GERD + and GERD - patients had similar lev...Continue Reading

References

Jun 1, 1983·Acta Psychiatrica Scandinavica·A S Zigmond, R P Snaith
Dec 12, 2001·Alimentary Pharmacology & Therapeutics·B AvidanS J Sontag
Jul 19, 2002·ANZ Journal of Surgery·Colm J O'BoyleGlyn G Jamieson
Aug 25, 2006·The American Journal of Gastroenterology·Nimish VakilUNKNOWN Global Consensus Group
Apr 18, 2008·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K W Olden
May 8, 2008·Digestive Diseases and Sciences·Ma Henar Núñez-Rodríguez, Alberto Miranda Sivelo
Jun 4, 2010·Arquivos De Gastroenterologia·Joaquim Prado P Moraes-FilhoUNKNOWN Brazilian Gerd Consensus Group
Apr 17, 2012·Journal of Digestive Diseases·Juanda Leo HartonoKhean-Lee Goh
Dec 7, 2013·World Journal of Surgery·Sebastião Carlos Pannocchia NetoMarco G Patti
Dec 17, 2014·Clinical Gastroenterology and Hepatology : the Official Clinical Practice Journal of the American Gastroenterological Association·Boudewijn F KessingAndré J P M Smout
Apr 22, 2015·World Journal of Gastroenterology : WJG·Xiao-Jun YangJun Song
Sep 26, 2015·Journal of Gastrointestinal Surgery : Official Journal of the Society for Surgery of the Alimentary Tract·Leonardo M Del GrandeMarco G Patti
May 5, 2016·Gastroenterology·Qasim AzizFrank Zerbib
May 25, 2016·Journal of Laparoendoscopic & Advanced Surgical Techniques. Part a·Ciro AndolfiMarco G Patti
Aug 28, 2016·Digestive Diseases and Sciences·Mustafa Melih BilgiSerhat Bor
Aug 31, 2016·Scandinavian Journal of Gastroenterology·Masatsugu OkuyamaYasuhiro Fujiwara
Oct 6, 2017·Electronic Physician·Seyed Alireza Haji Seyed Javadi, Ali Akbar Shafikhani
Mar 13, 2018·Alimentary Pharmacology & Therapeutics·T H TaftJ E Pandolfino

❮ Previous
Next ❯

Citations

Feb 26, 2021·The American Surgeon·Fernando A M Herbella, Marco G Patti

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus
B F NadaletoMarco G Patti
© 2022 Meta ULC. All rights reserved