Minor psychiatric disorders and syncope: the role of psychopathology in the expression of vasovagal reflex

Psychotherapy and Psychosomatics
Dionyssios LeftheriotisDimitrios Th Kremastinos

Abstract

A high prevalence of minor psychiatric disorders (MPDs) has been reported in patients with vasovagal syncope (VVS). However, the relationship between the psychiatric substrate and syncope remains unclear. In order to test the hypothesis that MPDs may predispose to VVS, we assessed the prevalence of syncope, the response to head-up tilt test (HUTT) and the efficacy of psychiatric drug treatment in reducing syncopal episodes, in patients with recently diagnosed MPDs. The response to HUTT was compared with that in an equal number of matched (a) patients with VVS and (b) healthy controls. A high rate of patients with MPDs (58%) had a positive HUTT. Additionally, 45% had a history of syncope; among them, the rate of positive HUTT was identical to that in the VVS group (83%). Following psychiatric drug treatment, the number of patients with syncope decreased in the MPD group (6/67 from 30/67, p < 0.01). Psychiatric symptoms and quality of life were also improved. The number of syncopal spells decreased equally in the MPD and VVS groups (0.6 +/- 0.5 from 2.5 +/- 1.4, p < 0.01, and 0.7 +/- 0.5 from 2.7 +/- 1.3, p < 0.01, respectively). A high proportion of patients with MPDs experience syncope, associated with a high rate of positive H...Continue Reading

Citations

May 7, 2011·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Jacobus J C M RommeJohannes B Reitsma
May 9, 2009·Journal of the American College of Cardiology·David G Benditt, John T Nguyen
Feb 19, 2013·General Hospital Psychiatry·Chiara RafanelliBiagio Sassone
Feb 26, 2015·Frontiers in Neuroscience·Jessica A EcclesHugo D Critchley
Oct 6, 2016·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Panayota FlevariJohn Lekakis
Jun 8, 2018·Angiology·Theodora A ManolisAntonis S Manolis
Oct 3, 2012·Pediatrics·Thomas N HyphantisTheofilos M Kolettis

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