Minor Review: An Overview of a Synthetic Nanophase Bone Substitute

Materials
Steven J EppellJonathan Z Baskin

Abstract

Material is reviewed that consists of reconstituted collagen fibril gel mineralized in a manner that produces biomimetically sized nanoapatites intimately associated with the fibrils. This gel is formed into usable shapes with a modulus and strength that allow it to be surgically press fitted into bony defects. The design paradigm for the material is that the nanoapatites will dissolve into soluble Ca2+ as the collagen is degraded into RGD-containing peptide fragments due to osteoclastic action. This is intended to signal to the osteoclasts to continue removing the material in a biomimetic fashion similar to bony remodeling. Preliminary experiments in a subcutaneous rat model show that the material is biocompatible with respect to inflammatory and immunogenic responses, and that it supports cellular invasion. Preliminary experiments in a critical-sized mandibular defect in rats show that the material is resorbable and functions well as a bone morphogenetic 2 (BMP-2) carrier. We have produced a range of mechanical and biological responses by varying mechanical and chemical processing of the material.

References

Jan 1, 1975·Biomaterials, Medical Devices, and Artificial Organs·D B SwedlowJ L Katz
Nov 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T AkatsuT Suda
Jan 1, 1990·The Journal of Craniofacial Surgery·J O Hollinger, J C Kleinschmidt
Jan 1, 1990·The Cleft Palate Journal·M I Siegel, M P Mooney
Sep 1, 1989·Journal of Cellular Physiology·G Hattersley, T J Chambers
May 1, 1988·Plastic and Reconstructive Surgery·R E Holmes, H K Hagler
Feb 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·M A HortonM H Helfrich
Oct 1, 1995·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·H M KimM J Glimcher
May 8, 1998·Biochemical and Biophysical Research Communications·T KamedaM Kumegawa
Jun 18, 1998·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·U LiljenqvistP Renton
Mar 13, 1999·Journal of Molecular Biology·C ScheuflerM Hülsmeyer
Jun 24, 1999·Journal of Biomedical Materials Research·H UludagJ Wozney
Jul 9, 1999·Journal of Biomedical Materials Research·K OhuraN Matsuda
Jun 6, 2000·Advanced Drug Delivery Reviews·J O HollingerS R Winn
Apr 17, 2001·Tissue Engineering·D A ChakkalakalM H McGuire
Jan 5, 2002·Journal of Biomedical Materials Research·J ZieglerK-P Günther
Jul 10, 2002·International Journal of Oral and Maxillofacial Surgery·G SwennenH Schliephake
Jul 13, 2002·Journal of Biomedical Materials Research·Jianxi LuJean-Pierre Proust
Jan 11, 2003·Journal of Biomedical Materials Research. Part a·Ayako OyaneTakashi Nakamura
Mar 14, 2003·Journal of Biomedical Materials Research. Part a·Satoshi TakikawaDaisuke Togawa
May 2, 2003·Calcified Tissue International·W TongS J Eppell
May 7, 2003·Proceedings of the National Academy of Sciences of the United States of America·Huajian GaoPeter Fratzl
Nov 13, 2003·Journal of Biomedical Materials Research. Part a·S WenischR Schnettler
Sep 25, 2004·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·L Le GuehennecP Layrolle
Oct 8, 2004·Cell Transplantation·Soichiro ItohJunzo Tanaka
Mar 24, 2005·Journal of Cellular and Molecular Medicine·D Logeart-AvramoglouH Petite
Jun 2, 1978·Science·M B Tomson, G H Nancollas
May 11, 2012·Journal of Biomedical Materials Research. Part a·Jonathan Z BaskinSteven J Eppell
Feb 15, 2017·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Jonathan Z BaskinSteven J Eppell
Aug 16, 2017·World Journal of Orthopedics·Marios Lykissas, Ioannis Gkiatas

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Methods Mentioned

BETA
scanning electron microscopy
X-ray
atomic force microscopy
ELISA

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