PMID: 16612471Apr 14, 2006Paper

Minor segmental wall motion abnormalities detected in patients with Chagas' disease have adverse prognostic implications

Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas
A Pazin-FilhoBenedito C Maciel

Abstract

Recent data from our laboratory have shown that patients with the indeterminate form of Chagas' disease can have impairment of left ventricular contractility, as evaluated by the slope of the left ventricle end-systolic pressure-dimension relationship. We also showed that Chagas' disease patients with minimal baseline wall motion abnormalities detected by two-dimensional echocardiography have more intense contractility impairment when compared to patients with the indeterminate form of the disease without this abnormality. The prognostic implications of these findings have not been established. We evaluated 59 patients (37-76 years, mean = 55 years) with different clinical forms of Chagas' disease, who had normal left ventricular global systolic function at baseline (57.6 +/- 6.9%) and who had at least one additional echo during clinical follow-up (0.4-17.6; mean 4.6 years). Group 1 consisted of 14 patients with minor baseline left ventricle wall motion abnormalities and group 2 consisted of 45 patients without these abnormalities. During follow-up, global left ventricle systolic function deterioration was observed in 10 group 1 patients (71.4%) and in only 10 group 2 patients (22.2%; P < 0.005). Age and duration of follow-up w...Continue Reading

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Citations

Apr 6, 2012·Current Infectious Disease Reports·José A Pérez-MolinaRogelio López-Vélez
Jan 23, 2016·International Journal of Cardiology·Henrique Horta VelosoMauro Felippe Felix Mediano
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Sep 19, 2021·The International Journal of Cardiovascular Imaging·Fernando Fonseca França RibeiroMinna Moreira Dias Romano

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