Minority Recruitment Trends in Phase III Prostate Cancer Clinical Trials (2003 to 2014): Progress and Critical Areas for Improvement

The Journal of Urology
Ashwin S BalakrishnanBenjamin N Breyer

Abstract

American minority groups have been historically underrepresented in phase III prostate cancer clinical trials despite often having higher risk disease. We analyzed enrollment trends of major racial/ethnic groups in the United States in phase III prostate cancer trials between 2003 and 2014 compared to SEER (Surveillance, Epidemiology and End Results) incidence data. Phase III prostate cancer trials primarily enrolling patients from the United States were identified in the ClinicalTrials.gov database. Enrollment trends were analyzed for major racial/ethnic groups. Prostate cancer incidence data from the SEER registry were used to identify enrollment targets. The enrollment difference was determined by calculating the absolute difference between the percent of a racial/ethnic subgroup in the SEER registry population and the percent of that subgroup in the phase III prostate cancer trial population. Among 39 studies identified African American enrollment in therapeutic trials increased across the study period (p <0.001). The enrollment difference for African Americans was -9.0% (95% CI -7.6- -10.5, p <0.001) in 2003 to 2005 and 1.4% (95% CI 0.2-2.6, p = 0.020) in 2012 to 2014. However, African American men were under enrolled in m...Continue Reading

Citations

Feb 23, 2020·Journal of Racial and Ethnic Health Disparities·Kyle B ZunigaStacey A Kenfield
Jul 12, 2020·Clinical Trials : Journal of the Society for Clinical Trials·Jodi B Segal, UNKNOWN PRIORITIZE HCV Study Group
Jun 7, 2020·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Emily M RencsokLorelei A Mucci
May 13, 2021·American Society of Clinical Oncology Educational Book·Frank C CackowskiBradley Carthon
Aug 8, 2021·Prostate Cancer and Prostatic Diseases·Vadim S KoshkinRana McKay
Aug 28, 2021·European Urology Oncology·Brandon A MahalKosj Yamoah

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