PMID: 6108737Jan 1, 1981

Minoxidil

Annals of Internal Medicine
S L Linas, A S Nies

Abstract

Minoxidil is an orally active vasodilator for treatment of severe hypertension. In combination with diuretics and beta-adrenergic blocking agents, it is effective treatment for more than 80% of patients whose blood pressure has been inadequately controlled with combinations of other been inadequately controlled with combinations of other antihypertensive drugs. Major adverse reactions include reflex activation of the adrenergic nervous system, renal sodium retention, and hypertrichosis. Despite the possibility of adverse reactions, minoxidil is indicated in patients whose blood pressure cannot be controlled with conventional therapy, in persons with major adverse reactions to other drugs, and in patients who are candidates for bilateral nephrectomy for control of hypertension.

Citations

Jan 1, 1986·The Journal of Emergency Medicine·M S Catapano, J A Marx
Jun 21, 2001·The Journal of Clinical Hypertension·Domenic A Sica, T W Gehr
Aug 1, 1987·Pediatric Dermatology
May 28, 2013·International Journal of Hypertension·Silvio BorrelliRoberto Minutolo
Mar 1, 1983·International Journal of Dermatology·R M Ingles, T Kahn
Feb 1, 1983·Australian and New Zealand Journal of Medicine·R V JacksonR D Gordon
May 11, 2004·The Journal of Clinical Hypertension·Domenic A Sica
Apr 1, 1990·DICP : the Annals of Pharmacotherapy·L J MiwaB W Shaw
Apr 29, 2020·Animals : an Open Access Journal From MDPI·Eduardo Naranjo-VázquezGuillermo Moisés Zúñiga-González
Nov 15, 1984·Postgraduate Medicine·B M Orme, R H Hegstrom
Aug 20, 2019·European Journal of Medicinal Chemistry·Rajesh KumarBijo Mathew

Related Concepts

Adrenergic beta-Antagonists
Angina Pectoris
Diuretic Effect
Polychemotherapy
Hypertensive Disease
Hypertrichosis
Kidney
U 10858
Natriuresis
Pyrimidines

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