Abstract
Minoxidil is an orally active vasodilator for treatment of severe hypertension. In combination with diuretics and beta-adrenergic blocking agents, it is effective treatment for more than 80% of patients whose blood pressure has been inadequately controlled with combinations of other been inadequately controlled with combinations of other antihypertensive drugs. Major adverse reactions include reflex activation of the adrenergic nervous system, renal sodium retention, and hypertrichosis. Despite the possibility of adverse reactions, minoxidil is indicated in patients whose blood pressure cannot be controlled with conventional therapy, in persons with major adverse reactions to other drugs, and in patients who are candidates for bilateral nephrectomy for control of hypertension.
Citations
Dec 1, 1990·Cardiovascular Drugs and Therapy·B HasselgrenB Wall
Mar 1, 1988·Cardiovascular Drugs and Therapy·G K JettR E Clark
Jan 1, 1988·Toxicology·E H HermanT Balazs
Jan 1, 1986·The Journal of Emergency Medicine·M S Catapano, J A Marx
Jun 21, 2001·The Journal of Clinical Hypertension·D A Sica, T W Gehr
Aug 1, 1987·Pediatric Dermatology
May 28, 2013·International Journal of Hypertension·Silvio BorrelliRoberto Minutolo
Sep 1, 1988·Drug Intelligence & Clinical Pharmacy·B H AckermanA B Bryan
Mar 1, 1983·International Journal of Dermatology·R M Ingles, T Kahn
Feb 1, 1983·Australian and New Zealand Journal of Medicine·R V JacksonR D Gordon
May 20, 2003·Clinical Genetics·M Tadin-StrappsA M Christiano
May 11, 2004·The Journal of Clinical Hypertension·Domenic A Sica
Apr 1, 1990·DICP : the Annals of Pharmacotherapy·L J MiwaB W Shaw
Sep 25, 2020·Dermatology and Therapy·Ratchathorn Panchaprateep, Suparuj Lueangarun
Apr 29, 2020·Animals : an Open Access Journal From MDPI·Eduardo Naranjo-VázquezGuillermo Moisés Zúñiga-González
Nov 15, 1984·Postgraduate Medicine·B M Orme, R H Hegstrom
Aug 20, 2019·European Journal of Medicinal Chemistry·Rajesh KumarBijo Mathew
Jun 9, 2019·Cellular Signalling·W FhayliG Faury
Mar 23, 2021·British Journal of Pharmacology·Yeong Chan RyuKang-Yell Choi
Sep 1, 1989·Progress in Cardiovascular Diseases·M C Houston
Apr 28, 2004·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Luca De NicolaUNKNOWN investigators of the TArget Blood Pressure LEvels in Chronic Kidney Disease (TABLE in CKD) Study Group
Oct 9, 2021·Journal of Medical Case Reports·Ramesh VenkateshNaresh Kumar Yadav