Mint1, a Munc-18-interacting protein, is expressed in insulin-secreting beta-cells

Biochemical and Biophysical Research Communications
Wei ZhangBjörn Meister

Abstract

Munc-18-interacting (Mint) proteins are adaptors involved in regulation of synaptic vesicle exocytosis. We have investigated expression and cellular localization of Mint1 in pancreatic islets with special reference to insulin-secreting beta-cells. Western blotting showed that Mint1 was expressed in hamster (HIT-T15) and rat (RINm5F) beta-cell lines. Mint1 immunoreactivity was preferentially localized to the periphery of individual islet cells. RT-PCR analysis revealed that apart from Mint1, RINm5F cells and rat islets also transcribed the mRNAs for Mint2 and Mint3. Expression of Mint proteins in pancreatic beta-cells suggests a functional role for these proteins in insulin granule exocytosis.

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Citations

Dec 6, 2011·DNA and Cell Biology·Ka-Ho ChaiKwok-Fai Lau
Nov 26, 2004·Molecular Biology of the Cell·Leonora F CiufoAlan Morgan
Jan 23, 2008·Traffic·Alejandra TomasPhilippe A Halban
Jun 13, 2006·Brain Research Reviews·Boris RogeljDeclan M McLoughlin
Aug 6, 2005·Molecular Endocrinology·Laurent WaselleRomano Regazzi
May 17, 2008·Biochemical Society Transactions·Sebastian BargStefanie Obermüller
Dec 23, 2014·Basic & Clinical Pharmacology & Toxicology·Anne Wuttke

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