Miocamycin distribution in tonsillar and pulmonary tissues after repeated administration

Journal of Chemotherapy
F ScaglioneF Fraschini

Abstract

Twenty patients undergoing tonsillectomy were treated with a peroral administration of 600 mg of miocamycin every 12 hours for 4 days. On the 5th day, after a last administration of a dose of 600 mg the ablation of the tonsils was carried out on groups of 4 subjects, each one at the following times after oral intake of the drug: 2, 4, 6, 8, 12 h. Twenty-nine patients, admitted to hospital to undergo lung resection were treated with peroral administration of miocamycin in accordance with the above mentioned dose scheme. The operation was carried out on groups of 5 subjects, each on the fifth day at the following times after the last administration: 2, 3, 4, 6, 8 and 12 h (4 subjects). Simultaneously blood was withdrawn for the determination of miocamycin in serum. Miocamycin was measured by a microbiological procedure using Sarcina lutea ATCC 9341. The highest levels of miocamycin were observed after 2h in tonsils (3.2 +/- 0.82 mg/kg) and serum (1.3 +/- 0.33 mg/l). After 12h miocamycin proved to be still measurable in the tissue (0.12 +/- 0.05 mg/kg), whereas it was not detected in serum. In pulmonary tissue, the highest levels of miocamycin were likewise identified at the 2nd hour (2.82 +/- 0.59 mg/kg), simultaneously with the ...Continue Reading

References

Dec 1, 1990·Journal of Chemotherapy·F VarottoF Fraschini
Sep 1, 1988·Antimicrobial Agents and Chemotherapy·G B GaliotoG Privitera
Dec 1, 1988·Antimicrobial Agents and Chemotherapy·G BenoniM E Fracasso
Jan 1, 1988·Chemotherapy·D PavesioM G Peisino
Jan 1, 1988·Chemotherapy·F FraschiniM Montanari
Jan 1, 1985·Current Medical Research and Opinion·M FalchiF Fraschini
Jan 1, 1984·The Journal of Antimicrobial Chemotherapy·R W LaceyG L Howson

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Citations

Jan 1, 1991·Acta Oto-laryngologica·F FraschiniG P Pintucci

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