MIP-1alpha as a critical macrophage chemoattractant in murine wound repair

The Journal of Clinical Investigation
L A DiPietroR M Strieter

Abstract

At sites of injury, macrophages secrete growth factors and proteins that promote tissue repair. While this central role of the macrophage has been well studied, the specific stimuli that recruit macrophages into sites of injury are not well understood. This study examines the role of macrophage inflammatory protein 1alpha (MIP-1alpha), a C-C chemokine with monocyte chemoattractant capability, in excisional wound repair. Both MIP-1alpha mRNA and protein were detectable in murine wounds from 12 h through 5 d after injury. MIP-1alpha protein levels peaked 3 d after injury, coinciding with maximum macrophage infiltration. The contribution of MIP-1alpha to monocyte recruitment into wounds was assessed by treating mice with neutralizing anti-MIP-1alpha antiserum before injury. Wounds of mice treated with anti-MIP-1alpha antiserum had significantly fewer macrophages than control (41% decrease, P < 0. 01). This decrease in wound macrophages was paralleled by decreased angiogenic activity and collagen synthesis. When tested in the corneal micropocket assay, wound homogenates from mice treated with anti-MIP-1alpha contained significantly less angiogenic activity than control wound homogenates (27% positive for angiogenic activity versus ...Continue Reading

References

Oct 1, 1977·Nature·P J PolveriniE R Unanue
Sep 1, 1991·Developmental Biology·D J Whitby, M W Ferguson
Dec 1, 1990·The Journal of Clinical Investigation·T J StandifordR M Strieter
Jan 1, 1989·Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research·M FukasawaG S Dizerega
Mar 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D DanonG S Roth
Oct 1, 1981·European Journal of Immunology·J M Austyn, S Gordon
Aug 1, 1993·Immunological Investigations·M D BurdickR M Strieter
Jan 1, 1994·American Journal of Respiratory Cell and Molecular Biology·G M VanOtterenR M Strieter

❮ Previous
Next ❯

Citations

Feb 10, 2000·Springer Seminars in Immunopathology·U SyrbeA Hamann
Jun 12, 2002·International Journal of Legal Medicine·T KondoW Eisenmenger
Feb 10, 2004·Progress in Retinal and Eye Research·Linda Dondero Hazlett
May 26, 2005·Toxicology and Applied Pharmacology·Neera V GopeePaul C Howard
Aug 30, 2005·Molecular Therapy : the Journal of the American Society of Gene Therapy·Sashwati RoyChandan K Sen
Oct 15, 2003·Burns : Journal of the International Society for Burn Injuries·Hilda ShalloElizabeth J Kovacs
Jul 12, 2011·Expert Reviews in Molecular Medicine·Timothy J Koh, Luisa Ann DiPietro
Mar 6, 2002·Clinical and Experimental Immunology·R N BarkerA J Rees
Apr 20, 2005·The Journal of Experimental Medicine·Julie M JamesonWendy L Havran
Apr 16, 2013·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·Alexey V KostarnoyAlexandr L Gintsburg
Aug 8, 2006·Tissue Engineering·Daniël T LuttikhuizenMarja J A Van Luyn
Nov 17, 2009·Tissue Engineering. Part a·Paul W Riem VisJolanda Kluin
Feb 3, 2011·Tissue Engineering. Part C, Methods·Daphne van GeemenCarlijn V C Bouten
Nov 13, 1998·Current Opinion in Lipidology·R TerkeltaubL K Curtiss
May 9, 2001·Current Opinion in Nephrology and Hypertension·L P ErwigA J Rees
Jul 12, 2005·The Journal of Burn Care & Rehabilitation·Abelardo MedinaEdward E Tredget
Mar 26, 2009·Plastic and Reconstructive Surgery·Aleksandra KrajewskiRajiv Y Chandawarkar
May 29, 2008·Molecular and Cellular Biology·Morvarid Mohseni, Athar H Chishti
Jan 20, 2009·American Journal of Respiratory and Critical Care Medicine·Amrita D JoshiCory M Hogaboam
Dec 19, 2002·The Journal of Clinical Investigation·Masashi NishidaIekuni Ichikawa
Dec 22, 2011·Journal of Inflammation·Marie At MatiasCamile S Farah
Jan 1, 2010·Journal of Leukocyte Biology·Leanne C Huysentruyt, Michael S McGrath
Jan 14, 2012·Endocrine Reviews·Jia-Ming Xu, Guo-Ping Shi
Jun 6, 2013·International Journal of Inflammation·Betsy J EvansR Clive Landis
Nov 21, 2013·Journal of Dermatological Science·Hiraku SugaShinichi Sato
Dec 11, 2013·Translational Stroke Research·Koji Hosaka, Brian L Hoh
Jun 8, 2012·ISRN Dermatology·K J Rolfe, A O Grobbelaar
May 20, 2014·The Journal of Clinical Investigation·Saeid Amini-NikBenjamin A Alman
Apr 11, 2000·Journal of Molecular and Cellular Cardiology·C KishimotoH Ochiai
Nov 3, 2005·Leukemia & Lymphoma·Evangelos TerposAmin Rahemtulla
Feb 13, 2016·Molecular and Cellular Endocrinology·M van de VyverW F Ferris
Oct 2, 2001·Cancer Investigation·S DiasS Rafii

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.