miR-101 represses lung cancer by inhibiting interaction of fibroblasts and cancer cells by down-regulating CXCL12

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Jian ZhangLijia Gu

Abstract

Cancer-associated fibroblasts (CAFs) are the main component of tumor stroma which support tumor progression. Here, we set out to determine the factors that may be involved in dramatic alteration of microRNAs (miRNAs) expression pattern in CAFs. miRNAs analyses identified differential expression of 15 microRNAs, with miR-101 being the most downregulated miRNA in CAFs which were different from the normal fibroblasts. We examined several putative miR-101 target genes identified by microarray analysis and demonstrated that miR-101 directly targets CXCL12, which play important roles in CAFs. Overexpression of miR-101 significantly impaired the ability of CAFs to stimulate tumor cell proliferation, sphere formation migration and invasion, and enhanced apoptosis. Further research showed that the cellular biological behavior was regulated by miR-101 targeting CXCL12. These findings provide new insights miR-101 down-regulation in CAFs could inhibit lung cancer proliferation and metastasis via targeting CXCL12.

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Citations

May 28, 2016·Molecular Cancer·Jamie N Frediani, Muller Fabbri
Oct 14, 2016·Journal of Human Genetics·Nijiro NohataJ Silvio Gutkind
Oct 23, 2018·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yijun TianKenkichi Sugimoto
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Apr 4, 2021·Cancers·Maria Teresa Di MartinoPierfrancesco Tassone
Apr 4, 2021·International Journal of Molecular Sciences·Sanith CheriyamundathAvri Ben-Ze'ev
Mar 30, 2021·Briefings in Bioinformatics·Jingru WangQing Li
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Jun 11, 2021·Signal Transduction and Targeted Therapy·Fanglong WuHongmei Zhou
Jun 11, 2021·Wiley Interdisciplinary Reviews. RNA·Subhashis NatuaSanjeev Shukla

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