Abstract
Wnt/β-catenin signaling pathway is strictly controlled by multiple negative regulators. However, how tumor cells override the negative regulatory effects to maintain constitutive activation of Wnt/β-catenin signaling, which is commonly observed in various cancers, remains puzzling. In current study, we reported that overexpression of miR-1207 in ovarian cancer activated Wnt/β-catenin signaling by directly targeting and suppressing secreted Frizzled-related protein 1 (SFRP1), AXIN2 and inhibitor of β-catenin and TCF-4 (ICAT), which are vital negative regulators of the Wnt/β-catenin pathway. We found that the expression of miR-1207 was ubiquitously upregulated in both ovarian cancer tissues and cells, which inversely correlated with patient overall survival. Furthermore, overexpression of miR-1207 enhanced, while silencing miR-1207 reduced, stem cell-like traits of ovarian cancer cells in vitro and in vivo, including tumor sphere formation capability and proportion of SP+ and CD133+ cells. Importantly, upregulating miR-1207 promoted, while silencing miR-1207 inhibited, the tumorigenicity of ovarian cancer cells. Hence, our results suggest that miR-1207 plays a vital role in promoting the cancer stem cell-like phenotype in ovarian...Continue Reading
References
Mar 9, 2002·Molecular and Cellular Biology·William C HahnRobert A Weinberg
Nov 1, 2002·Molecular Cell·Danette L Daniels, William I Weis
Nov 17, 2005·Cancer Research·Margaret S JoestingPaul C Marker
Sep 23, 2006·Cancer Research·Michael F ClarkeGeoffrey M Wahl
Dec 5, 2006·Oncogene·D Kimelman, W Xu
Sep 28, 2007·Breast Cancer Research : BCR·Thomas SchlangeNancy E Hynes
Feb 9, 2008·Cell Death and Differentiation·L VermeulenJ P Medema
Mar 29, 2008·Cell Stem Cell·Keiyo TakuboToshio Suda
Apr 4, 2008·Nature·Ilaria MalanchiJoerg Huelsken
Aug 7, 2008·Cell Stem Cell·Alexander MarsonRudolf Jaenisch
Oct 28, 2008·Acta Obstetricia Et Gynecologica Scandinavica·Charlotte Gerd HannibalSusanne Krüger Kjaer
Nov 26, 2008·Cold Spring Harbor Symposia on Quantitative Biology·R NusseY Kalani
Jul 8, 2009·Annals of Surgical Oncology·Anna Fen-Yau LiHan-Shui Hsu
Jul 22, 2009·Developmental Cell·Bryan T MacDonaldXi He
Sep 19, 2009·Methods in Molecular Biology·Carolyn G MarsdenBrian G Rowan
Mar 27, 2010·Science·Yingzi WangScott A Armstrong
Jun 26, 2010·Circulation Research·Tata Purushothama Rao, Michael Kühl
Nov 12, 2010·Medical Oncology·Ergun PinarbasiYavuz Silig
Jul 14, 2011·Neoplasia : an International Journal for Oncology Research·Fu YangShu-han Sun
Dec 7, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Adam D StegCharles N Landen
May 5, 2012·Gynecologic Oncology·Michele PeirettiAngelo Maggioni
Jul 17, 2012·Oncogene·W K ChauA S T Wong
Sep 29, 2012·Current Pharmaceutical Design·Andrey Voronkov, Stefan Krauss
Jan 30, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Radoslav ChekerovJalid Sehouli
Jun 20, 2013·Cell·Judy LiebermanJoshua T Mendell
Aug 2, 2013·Journal of Experimental & Clinical Cancer Research : CR·Federica TomaoSilverio Tomao
Oct 16, 2013·Gynecologic Oncology·Rebecca C ArendDonald J Buchsbaum
Nov 28, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jun LiuJennifer L Harris
Feb 12, 2014·Cancer Research·Mélanie J DominguesJacky Bonaventure
May 24, 2014·Cell Death & Disease·I RamachandranL Queimado
Jul 2, 2014·Nature Reviews. Drug Discovery·Diwakar R Pattabiraman, Robert A Weinberg
Jul 19, 2014·PloS One·Laura HuthEdgar Dahl
Nov 2, 2014·Cell Death and Differentiation·T-H HsuT-C Chang
Citations
Apr 24, 2016·Oncotarget·Wei DangJian Ma
Dec 22, 2016·Oncotarget·James A McCubreyMassimo Libra
Jun 22, 2017·Oncotarget·Wenzhi GuoHua Ye
Oct 17, 2019·Journal of Clinical Medicine·Miriam Teeuwssen, Riccardo Fodde
Sep 12, 2019·Frontiers in Oncology·Olorunseun O Ogunwobi, Adithya Kumar
Feb 23, 2020·Cancers·Rashidah BaharudinNurul Syakima Ab Mutalib
Apr 6, 2020·Inflammation·Xiuyi LiYan Long
Feb 28, 2019·Oncogene·Yicun WangRunhua Liu
Jul 3, 2019·Cancers·Takeshi Motohara, Hidetaka Katabuchi
Nov 30, 2019·Frontiers in Oncology·Ariadna BoloixMiguel F Segura
Jul 19, 2018·Future Oncology·Shuang WangZheng Jiang
Jan 19, 2019·Oncology Letters·Xiaoke HouXia Zhang
Nov 9, 2017·Oncotarget·Zhuo YangLing OuYang
Feb 25, 2017·Cancer Science·Chen YanYuhua Yuan
Aug 8, 2017·Oncogene·J LiQ C Zheng
Jun 24, 2017·Expert Opinion on Biological Therapy·Victoria MandilarasStephanie Lheureux
Oct 22, 2020·International Journal of Molecular Sciences·Malvina KoniMaria Felice Brizzi
Jun 14, 2018·PloS One·Ferah BudakHaluk Barbaros Oral
Dec 13, 2019·Journal of Ovarian Research·Vu Hong Loan NguyenChun Peng
Feb 14, 2016·Molecular Cancer Therapeutics·Fan WangR Stephanie Huang
Jan 14, 2021·Scientific Reports·Mohamed K HassanSherif F El-Khamisy
Sep 19, 2019·Cells·Abdul Q KhanShahab Uddin
Sep 20, 2019·Microorganisms·Shunbin Xu, Linda D Hazlett
Apr 22, 2020·Therapeutic Advances in Medical Oncology·David W DooRebecca C Arend
Apr 4, 2021·Cancers·Shailendra Kumar Dhar DwivediResham Bhattacharya
Aug 7, 2021·Biomolecules·Chao-Lien LiuTsui-Lien Mao