MiR-1207 overexpression promotes cancer stem cell-like traits in ovarian cancer by activating the Wnt/β-catenin signaling pathway

Oncotarget
Geyan WuShanyang He

Abstract

Wnt/β-catenin signaling pathway is strictly controlled by multiple negative regulators. However, how tumor cells override the negative regulatory effects to maintain constitutive activation of Wnt/β-catenin signaling, which is commonly observed in various cancers, remains puzzling. In current study, we reported that overexpression of miR-1207 in ovarian cancer activated Wnt/β-catenin signaling by directly targeting and suppressing secreted Frizzled-related protein 1 (SFRP1), AXIN2 and inhibitor of β-catenin and TCF-4 (ICAT), which are vital negative regulators of the Wnt/β-catenin pathway. We found that the expression of miR-1207 was ubiquitously upregulated in both ovarian cancer tissues and cells, which inversely correlated with patient overall survival. Furthermore, overexpression of miR-1207 enhanced, while silencing miR-1207 reduced, stem cell-like traits of ovarian cancer cells in vitro and in vivo, including tumor sphere formation capability and proportion of SP+ and CD133+ cells. Importantly, upregulating miR-1207 promoted, while silencing miR-1207 inhibited, the tumorigenicity of ovarian cancer cells. Hence, our results suggest that miR-1207 plays a vital role in promoting the cancer stem cell-like phenotype in ovarian...Continue Reading

References

Mar 9, 2002·Molecular and Cellular Biology·William C HahnRobert A Weinberg
Feb 9, 2008·Cell Death and Differentiation·L VermeulenJ P Medema
Aug 7, 2008·Cell Stem Cell·Alexander MarsonRudolf Jaenisch
Oct 28, 2008·Acta Obstetricia Et Gynecologica Scandinavica·Charlotte Gerd HannibalSusanne Krüger Kjaer
Nov 26, 2008·Cold Spring Harbor Symposia on Quantitative Biology·R NusseY Kalani
Jul 22, 2009·Developmental Cell·Bryan T MacDonaldXi He
Sep 19, 2009·Methods in Molecular Biology·Carolyn G MarsdenBrian G Rowan
Jun 26, 2010·Circulation Research·Tata Purushothama Rao, Michael Kühl
Nov 12, 2010·Medical Oncology·Ergun PinarbasiYavuz Silig
Jul 14, 2011·Neoplasia : an International Journal for Oncology Research·Fu YangShu-han Sun
Dec 7, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Adam D StegCharles N Landen
Sep 29, 2012·Current Pharmaceutical Design·Andrey Voronkov, Stefan Krauss
Jan 30, 2013·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Radoslav ChekerovJalid Sehouli
Jun 20, 2013·Cell·Judy LiebermanJoshua T Mendell
Oct 16, 2013·Gynecologic Oncology·Rebecca C ArendDonald J Buchsbaum
Nov 28, 2013·Proceedings of the National Academy of Sciences of the United States of America·Jun LiuJennifer L Harris
Feb 12, 2014·Cancer Research·Mélanie J DominguesJacky Bonaventure
May 24, 2014·Cell Death & Disease·I RamachandranL Queimado
Jul 2, 2014·Nature Reviews. Drug Discovery·Diwakar R Pattabiraman, Robert A Weinberg

❮ Previous
Next ❯

Citations

Oct 17, 2019·Journal of Clinical Medicine·Miriam Teeuwssen, Riccardo Fodde
Sep 12, 2019·Frontiers in Oncology·Olorunseun O Ogunwobi, Adithya Kumar
Feb 23, 2020·Cancers·Rashidah BaharudinNurul Syakima Ab Mutalib
Nov 30, 2019·Frontiers in Oncology·Ariadna BoloixMiguel F Segura
Jun 24, 2017·Expert Opinion on Biological Therapy·Victoria MandilarasStephanie Lheureux
Oct 22, 2020·International Journal of Molecular Sciences·Malvina KoniMaria Felice Brizzi
Sep 20, 2019·Microorganisms·Shunbin Xu, Linda D Hazlett
Apr 22, 2020·Therapeutic Advances in Medical Oncology·David W DooRebecca C Arend
Apr 4, 2021·Cancers·Shailendra Kumar Dhar DwivediResham Bhattacharya
Aug 7, 2021·Biomolecules·Chao-Lien LiuTsui-Lien Mao

❮ Previous
Next ❯

Datasets Mentioned

BETA
E-MTAB-1067

Methods Mentioned

BETA
PCR
Xenograft
transfection
acylation
Assay
flow cytometry

Software Mentioned

FlowJo
miRanda
TargetScan6
TargetScan
SPSS

Related Concepts

Related Feeds

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.