miR-122-induced down-regulation of HO-1 negatively affects miR-122-mediated suppression of HBV

Biochemical and Biophysical Research Communications
Lipeng QiuSongdong Meng

Abstract

As the most abundant liver-specific microRNA (miRNA), miR-122 has been extensively studied for its role in the regulation of lipid metabolism, hepatocarcinogenesis and hepatitis C virus (HCV) replication, but little is known regarding its role in the replication of Hepatitis B virus (HBV), a highly prevalent hepatotropic virus that can cause life-threatening complications. In this study we examined the effects of antisense inhibition of miR-122 and transfection of a miR-122 mimic on HBV expression in hepatoma cells. The over-expression of miR-122 inhibited HBV expression, whereas the depletion of endogenous miR-122 resulted in increased production of HBV in transfected cells. We further found that the down-regulation of Heme oxygenase-1 (HO-1) by miR-122 plays a negative role in the miR-122-mediated inhibition of viral expression. Our study demonstrates the anti-HBV activity of miR-122, suggesting that therapies that increase miR-122 and HO-1 may be an effective strategy to limit HBV replication.

References

May 15, 2002·Current Biology : CB·Mariana Lagos-QuintanaThomas Tuschl
Sep 6, 2005·Science·Catherine L JoplingPeter Sarnow
Nov 1, 2005·Nature·Jan KrützfeldtMarkus Stoffel
Feb 22, 2008·Current Pharmaceutical Design·Z W XiaZ L Zhang
Feb 23, 2008·Journal of Hepatology·Muriel GirardAlexandra Henrion-Caude
Mar 15, 2008·Virus Research·Michael Nassal
Jun 21, 2008·Journal of Gastroenterology and Hepatology·Anthony Tanoto TanAntonio Bertoletti
Sep 3, 2008·Journal of Gastroenterology and Hepatology·Amitis RamezaniAli Akbar Velayati
Sep 19, 2008·Journal of Virology·Anthony Tanoto TanAntonio Bertoletti
Nov 21, 2008·The EMBO Journal·Jura Inga HenkeMichael Niepmann
Jan 6, 2009·Nature Medicine·Magdalena Sarasin-FilipowiczWitold Filipowicz
Jan 29, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Shunsuke UraShuichi Kaneko
Mar 20, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Wei-Chih TsaiAnn-Ping Tsou
Jan 2, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Elisabeth LehmannGabriele Sass
Jan 26, 2010·Nature Reviews. Immunology·Ryan M O'ConnellDavid Baltimore
Jan 29, 2010·Immune Network·Hyun-Ock Pae, Hun-Taeg Chung

❮ Previous
Next ❯

Citations

Feb 4, 2011·Journal of Biosciences·Dwaipayan Adhya, Anirban Basu
May 22, 2013·Nature Reviews. Gastroenterology & Hepatology·Gyongyi Szabo, Shashi Bala
Mar 10, 2011·PloS One·Viraj R Sanghvi, Laura F Steel
Apr 6, 2012·PloS One·Wei HuShengqi Wang
Nov 12, 2013·Viruses·Muriel Thirion, Takahiro Ochiya
Jun 3, 2011·World Journal of Gastroenterology : WJG·Ashley M LaknerLaura W Schrum
Aug 16, 2013·World Journal of Gastroenterology : WJG·Ying-Feng WeiHong-Yan Diao
Sep 24, 2013·Antioxidants & Redox Signaling·Magdalena KozakowskaAlicja Jozkowicz
Oct 16, 2013·Antioxidants & Redox Signaling·Raffaella Gozzelino, Miguel P Soares
Jan 3, 2014·Antioxidants & Redox Signaling·Phyllis A Dennery
Sep 12, 2012·Journal of Gastroenterology·Takasuke Fukuhara, Yoshiharu Matsuura
Aug 8, 2015·International Journal of Molecular Sciences·Neelakshi Sarkar, Runu Chakravarty
Dec 21, 2013·Expert Opinion on Investigational Drugs·Zhihua Qiu, Yimin Dai
Dec 1, 2015·Biomarkers : Biochemical Indicators of Exposure, Response, and Susceptibility to Chemicals·J M Falcon-Perez, F Royo
Mar 17, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Vicky Nicolaidou, Costas Koufaris
May 14, 2011·Biochimica Et Biophysica Acta·Wan-Hsin LiuPei-Jer Chen
Apr 26, 2011·Mutation Research·Bahaeldin K ElaminMassimo Negrini
Mar 23, 2011·Translational Research : the Journal of Laboratory and Clinical Medicine·Thomas A KerrNicholas O Davidson
Oct 31, 2012·Science China. Life Sciences·Xue ZhaoHaitao Zhao
Nov 23, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Saifeng WangSongdong Meng
Oct 14, 2014·Journal of Hepatology·Simonetta BandieraMirjam B Zeisel
Dec 5, 2012·Journal of Nucleic Acids·Juan Wang, Qinghua Cui
May 16, 2014·Biochemical and Biophysical Research Communications·Nicola MoscaNicoletta Potenza
Apr 17, 2012·Journal of Hepatology·Gyongyi SzaboShashi Bala
Dec 21, 2010·Cancer Letters·Michael J Bouchard, Sonia Navas-Martin
Dec 3, 2014·The Journal of Infection·Sakura AkamatsuKazuaki Chayama
Apr 11, 2015·Frontiers in Oncology·Kaveri SidhuVijay Kumar

❮ Previous
Next ❯

Related Concepts

Related Feeds

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.