miR-125a-5p expression is associated with the age of breast cancer patients

Genetics and Molecular Research : GMR
H HeR H Duan

Abstract

Dysregulated miR-125 observed in multiple cancer types has suggested that it is involved in malignant proliferation and invasion. However, the clinical significance of miR-125 in human breast cancer (BC) has not yet been fully elucidated. In the present study, the expression of miR-125a-5p/3p and miR-125b in 143 pairs of BC and normal adjacent tissues (NATs) was measured by real-time quantitative PCR, and the correlation between expression and clinicopathological features was explored. miR-125a-5p and miR-125b were significantly down-regulated in BC tissue samples compared with their matched NAT samples, while the difference in miR-125a-3p expression between BC tissues and NATs was not statistically significant. The expression level of miR-125a-5p was found to be significantly higher in younger patients (<35 years) than in older patients (≥35, P = 0.005). When the patients were divided into three groups according to age (<35, 36-48, and ≥48 years), a gradual reduction in miR-125a-5p expression was observed in BC tissue samples that correlated to increases in age (P = 0.009). There were no significant correlations between miR-125 expression and other clinicopathological features including tumor size, histological grade, hormone ...Continue Reading

Citations

Oct 25, 2016·Frontiers in Pharmacology·Jorge L Gutierrez-PajaresPhilippe G Frank
Feb 12, 2017·The Journal of Biological Chemistry·Masataka NakanoMiki Nakajima
Oct 3, 2019·British Journal of Biomedical Science·S RamezaniS Alizadehsefat

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