MiR-126-5p regulates osteoclast differentiation and bone resorption in giant cell tumor through inhibition of MMP-13

Biochemical and Biophysical Research Communications
Zhipeng WuJianru Xiao

Abstract

Giant cell tumor (GCT) of bone is an aggressive skeletal tumor characterized by localized bone resorption. Matrix metalloproteinase-13 (MMP-13) is the principal proteinase expressed by the stromal cells of GCT (GCTSCs) and also considered to play a crucial role in formation of the osteolytic lesion in GCT. However, the exact mechanism of the regulation of MMP-13 expression in GCTSCs was unknown. In this study, we identified miR-126-5p was significantly downregulated in GCTSCs and affect osteoclast (OC) differentiation and bone resorption by repressing MMP-13 expression at the post-transcriptional level. Thus, our studies show that miR-126-5p plays an important physiological role in multinucleated giant cell formation and osteolytic lesion in GCT.

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Citations

Jan 30, 2015·European Spine Journal : Official Publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society·Huabin YinJianru Xiao
Sep 7, 2016·International Journal of Molecular Sciences·Chafik Ghayor, Franz E Weber
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Apr 8, 2018·Journal of Cellular Biochemistry·Vishal MohanakrishnanNagarajan Selvamurugan
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Mar 9, 2021·Technology and Health Care : Official Journal of the European Society for Engineering and Medicine·Bo DouZhaoli Meng

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