miR-1273g-3p participates in acute glucose fluctuation-induced autophagy, dysfunction, and proliferation attenuation in human umbilical vein endothelial cells

American Journal of Physiology. Endocrinology and Metabolism
Jun GuoYan Kang

Abstract

Acute glucose fluctuations (AGF) often cause high mortality among critically ill patients, but the mechanisms induced by AGF are not clear. Recent studies suggest that endothelial dysfunction is a key factor that leads to high mortality among critically ill patients. Our goal is to evaluate the phenomenon and mechanisms of endothelial dysfunction induced by AGF. In this study, the functions of human umbilical vein endothelial cells (HUVECs) were compared after treatment with sustained high glucose (SHG), AGF in two groups (AGF1 fluctuations between 5 and 16 mM and AGF2 fluctuations between 5 and 25 mM), and normal glucose levels as a control group (CTR). The medium of the groups was changed every 4 h. The influence of AGF on wound healing was also tested on C57BL/6 mice. The results show that cell proliferation, angiogenesis, and migration functions were injured in the SHG and both AGF groups. AGF2 group shows the worse condition in vitro. In vivo, the wound healing was delayed after the AGF treatment. Furthermore, the markers of apoptosis and autophagy were analyzed. We observed that the autophagy changed in all treatment groups, but apoptosis showed no change. To get to know the mechanism of dysfunction and autophagy, we perf...Continue Reading

References

Oct 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·A RissoA Ceriello
Feb 3, 2006·Diabetes/metabolism Research and Reviews·Ludovica PiconiAntonio Ceriello
Apr 13, 2006·JAMA : the Journal of the American Medical Association·Michael Brownlee, Irl B Hirsch
Dec 19, 2006·Trends in Biochemical Sciences·Jorge MoscatMarie W Wooten
Jul 6, 2007·Autophagy·Noboru Mizushima, Tamotsu Yoshimori
Oct 3, 2007·Nature Cell Biology·Zhiping Xie, Daniel J Klionsky
Oct 6, 2007·Arteriosclerosis, Thrombosis, and Vascular Biology·Giulio CeolottoAngelo Avogaro
Feb 8, 2008·American Journal of Physiology. Renal Physiology·Cheng YangGur P Kaushal
May 30, 2008·Molecular Biology of the Cell·Zhiping XieDaniel J Klionsky
May 30, 2008·Kidney International·Sudharsan Periyasamy-ThandavanZheng Dong
Jul 4, 2008·Critical Care Medicine·Naeem A AliJean-Charles Preiser
Dec 9, 2008·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Zhiwu DongJunying Miao
Apr 9, 2009·Biochemical and Biophysical Research Communications·Yangxin LiYong-Jian Geng
May 5, 2009·Autophagy·David C RubinszteinDaniel J Klionsky
May 20, 2009·Molecular Cell·Vladimir KirkinIvan Dikic
Nov 10, 2009·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Seung-Hong LeeYou-Jin Jeon
Jul 27, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·A Ceriello, M A Ihnat
Jan 14, 2011·Cancer Biology & Therapy·Ning Chen, Vassiliki Karantza
Jan 14, 2012·The Prostate·Ahamed SaleemRobert S DiPaola
Jan 17, 2013·Autophagy·Kumsal Ayse TekirdagDevrim Gozuacik
Aug 9, 2013·Intensive Care Medicine·Marcel Levi, Tom van der Poll
Sep 3, 2013·Biochimica Et Biophysica Acta·Cristina M SenaRaquel Seiça
Jun 3, 2014·Critical Care : the Official Journal of the Critical Care Forum·Michael J LanspaEliotte L Hirshberg
Jun 3, 2014·Critical Care : the Official Journal of the Critical Care Forum·Pedro KurtzStephan A Mayer

❮ Previous
Next ❯

Citations

Sep 22, 2017·Human Cell·Laura De-UgarteNatalia Garcia-Giralt
Apr 23, 2020·Anais Da Academia Brasileira De Ciências·Huan GuoYingdong Li
Oct 11, 2019·Precision Clinical Medicine·Qinqin PuMin Wu
Oct 18, 2019·Frontiers in Endocrinology·Zhen-Ye ZhangRu-Xing Wang
May 2, 2017·Frontiers in Oncology·Devrim GozuacikMuhammed Kocak
Aug 8, 2021·International Journal of Molecular Sciences·Vadim V KlimontovAnton I Korbut
Aug 28, 2021·International Journal of Molecular Sciences·Valentina AlfieriPaolo Poggio

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms

Related Papers

Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences
Zhimin Tang, Minxiang Lei
Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences
Xin-lei ChenZe-lian Qin
Ophthalmologica. Journal international d'ophtalmologie. International journal of ophthalmology. Zeitschrift für Augenheilkunde
Fang BianYun Zhu
© 2022 Meta ULC. All rights reserved