miR-1291 targets mucin 1 inhibiting cell proliferation and invasion to promote cell apoptosis in esophageal squamous cell carcinoma

Oncology Reports
Hailan LuoFuqing Wang

Abstract

MicroRNAs (miRNAs) are well known as important regulators in various cancer development. In the present study, we focused on the expression and biological function of miR-1291 in esophageal squamous cell carcinoma (ESCC). Compared with adjacent non-tumorous tissue samples, qRT-PCR data showed significant downregulation of miR-1291 in 54 ESCC tissue samples (P<0.05), which was also significantly associated with lymph node metastases and clinical stage (P<0.05). Cell Counting Kit-8 (CCK-8), colony formation, Transwell and flow cytometric apoptosis assays were performed to detect the effect of miR-1291 upregulation, and the results showed inhibition of the proliferation, invasion and promotion of apoptosis in EC9706 and EC-1 cells. Using bioinformatic analyses, we found that mucin 1 (MUC1) was a potential target for miR-1291. Luciferase assays were performed to reveal that miR-1291 inhibited MUC1 expression by targeting the seed region of MUC1 3'-untranslated region (3'UTR). We also found that the expression of MUC1 lacking in 3'UTR abrogated the anti-invasion and pro-apoptosis function of miR-1291. Our results demonstrated the importance of miR-1291 in targeting MUC1 for the regulation of esophagus cancer growth, invasion and apo...Continue Reading

References

Sep 17, 2004·Nature·Victor Ambros
Oct 27, 2004·PLoS Biology·Bino JohnDebora S Marks
Aug 15, 2006·Trends in Cell Biology·Pankaj K Singh, Michael A Hollingsworth
Mar 29, 2008·Science·Oliver Hobert
Nov 5, 2008·Cancer Biology & Therapy·Deepak RainaDonald Kufe
Feb 7, 2009·Diseases of the Esophagus : Official Journal of the International Society for Diseases of the Esophagus·T W RiceE H Blackstone
Jun 27, 2009·Cancer Biology & Therapy·Donald W Kufe
Nov 19, 2009·Journal of Surgical Oncology·Chikara KunisakiHirotoshi Akiyama
Nov 26, 2009·Nature Reviews. Cancer·Donald W Kufe
Mar 29, 2014·Trends in Molecular Medicine·Sritama Nath, Pinku Mukherjee
May 17, 2014·World Journal of Gastrointestinal Oncology·Kyle J NapierSubhasis Misra
Jul 9, 2014·Biochimica Et Biophysica Acta·Caroline GronnierIsabelle Van Seuningen
Oct 18, 2014·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Weiling LiYongfei Tan
Nov 12, 2014·Nature Reviews. Nephrology·Piera TrionfiniGiuseppe Remuzzi
Dec 3, 2014·FEBS Letters·Zhenqiang WangChen Li
Dec 17, 2014·International Journal of Oncology·Yuka IsozakiHisahiro Matsubara
Mar 26, 2015·World Journal of Gastroenterology : WJG·Ming LiRui-Hua Shi
Mar 31, 2015·Oncology Reports·Quanxing CaoYongsheng Wang
Apr 11, 2015·International Journal of Hypertension·Sudhiranjan Gupta, Li Li
Apr 19, 2015·BMC Immunology·Jeremy S SchaeferJohn R Klein
Apr 19, 2015·Journal of Ovarian Research·Yingying ZhouTing Shuang

❮ Previous
Next ❯

Citations

Jan 9, 2019·The Journal of International Medical Research·Juan LiYu-Xiang Wang
Sep 7, 2018·BioMed Research International·Shipeng ZhaoZhuo Wang
Sep 10, 2019·The Journal of Gene Medicine·Nuerbieke PulatiJie Yang
Aug 5, 2018·Science China. Life Sciences·Yuming WangLei Huang
Dec 22, 2020·Frontiers in Genetics·Daniel EscuinAgustí Barnadas
Apr 17, 2021·Biochimica Et Biophysica Acta. Reviews on Cancer·Nicolas JonckheereIsabelle Van Seuningen
Jun 22, 2021·Oncology Letters·Xiaojie SunXiangwei Meng

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis