MiR-1303 Regulates Mycobacteria Induced Autophagy by Targeting Atg2B

PloS One
Kin Yi AuJames C B Li

Abstract

MicroRNAs are emerging post-transcriptional regulators of gene expressions in both innate immunity and adaptive immunity. In mycobacteria infection, autophagy plays an important role in innate defense mechanism and is tightly regulated by the autophagy-related proteins. Here, we show that Atg2B is involved in the regulation of mycobacteria-induced autophagy. MiR-1303, which function is not defined yet, is found to negatively regulate mycobacteria-induced Atg2B protein production, ultimately down-regulate mycobacteria-induced autophagy. MiR-1303 production is shown to be upregulated during BCG infection and its production is regulated by PI3K and NFκB. It is also demonstrated that miR-1303 targets putative target sites on Atg2B and possibly represses its translation.

References

Nov 6, 2004·Science·Takahiro Shintani, Daniel J Klionsky
Apr 27, 2005·Nature Reviews. Molecular Cell Biology·V Narry Kim
Nov 17, 2005·Proceedings of the National Academy of Sciences of the United States of America·David T HumphreysThomas Preiss
Aug 31, 2006·Journal of Cell Science·Andrew R J YoungSharon A Tooze
Oct 3, 2007·Nature Cell Biology·Zhiping Xie, Daniel J Klionsky
Jan 15, 2008·Cell·Beth Levine, Guido Kroemer
Aug 1, 2008·Nature·Daehyun BaekDavid P Bartel
Jun 23, 2009·Immunology·Li-Fan Lu, Adrian Liston
Jul 15, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jin HouXuetao Cao
Oct 21, 2009·The Journal of Biological Chemistry·Md A NahidEdward K L Chan
Dec 26, 2009·Current Opinion in Cell Biology·Zhifen Yang, Daniel J Klionsky
Feb 23, 2010·Current Directions in Autoimmunity·Valerie F J QuesniauxBernhard Ryffel
Jul 28, 2010·Nature Reviews. Genetics·Jacek KrolWitold Filipowicz
Jan 20, 2011·Nature Reviews. Genetics·Eric Huntzinger, Elisa Izaurralde
Oct 8, 2011·Immunology·Johanneke KleinnijenhuisMihai G Netea
Nov 17, 2011·The EMBO Journal·Francesco Cecconi
Jun 6, 2012·RNA Biology·Ana EulalioJörg Vogel
Aug 21, 2012·Carcinogenesis·Lisa B Frankel, Anders H Lund

❮ Previous
Next ❯

Citations

Apr 26, 2017·Autophagy·Jian ZhangDa Pang
Aug 30, 2018·Frontiers in Immunology·Jessica C Hargarten, Peter R Williamson
Oct 11, 2019·Precision Clinical Medicine·Qinqin PuMin Wu
Feb 1, 2020·Biochimica Et Biophysica Acta. Molecular Cell Research·Yunus Akkoc, Devrim Gozuacik
Feb 22, 2021·Journal of Cellular and Molecular Medicine·Liang ZhengGuangqi Chang
Jul 3, 2021·European Journal of Applied Physiology·A ManciniP Buono

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
protein assay
transfection
ELISA

Software Mentioned

TargetScan
GraphPad Prism

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Autophagy & Model Organisms

Autophagy is a cellular process that allows degradation by the lysosome of cytoplasmic components such as proteins or organelles. Here is the latest research on autophagy & model organisms