miR-1306-3p targets FBXL5 to promote metastasis of hepatocellular carcinoma through suppressing snail degradation

Biochemical and Biophysical Research Communications
Zhi-Jiang HeYun-Jun Liu

Abstract

This study aimed to elucidate the effect of miR-1306-3p on metastasis of hepatocellular carcinoma (HCC) and potential mechanism involved. miR-1306-3p promoted migration and invasion of HCC in vivo and in vitro. Moreover, miR-1306-3p inhibited snail to enhance its expression via directly targeting FBXL5, thus inducing the epithelial-mesenchymal transition (EMT) in HCC. Intriguingly, miR-1306-3p expression was transcriptionally enhanced by FoxM1. Consistently, miR-1306-3p was upregulated in HCC compared with paracarcinoma and correlated with poor prognosis of HCC patients. Our researches suggest that miR-1306-3p is a tumor enhancer in regulating of HCC metastasis, and miR-1306-3p may be clinically utilized as a factor for the clinical diagnosis and prognosis of HCC.

Citations

May 31, 2019·Journal of Clinical Medicine·Josep BaulidaAntonio García de Herreros
Nov 11, 2019·Scientific Reports·Peipei PanMatilda F Chan
Mar 3, 2020·Frontiers in Genetics·Qiumei DuNicolai S C van Oers
Dec 14, 2018·International Journal of Molecular Sciences·Tae-Su HanHyun-Soo Cho
Sep 24, 2019·Cancer Letters·Min LinZhi-Wei Wang
Dec 27, 2019·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Linzhi YanXueqiong Zhu

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