MiR-137 acts as a tumor suppressor in papillary thyroid carcinoma by targeting CXCL12

Oncology Reports
Su DongJia Liu


Accumulating evidence has shown that aberrantly expressed microRNAs (miRs) are extensively involved in tumorigenesis. microRNA-137 (miR-137) has been reported as a tumor suppressor in various types of cancer. However, the biological function and underlying molecular mechanism of miR-137 in papillary thyroid carcinoma (PTC) remain largely unknown. Therefore, the present study aimed to investigate the expression pattern of miR-137 and its functional significance in PTC. Quantitative RT-PCR (qRT-PCR) assay showed that miR-137 expression was significantly downregulated in human PTC tissues, and its expression was significantly negatively correlated with tumor-node-metastasis (TNM) stage and lymph node metastasis. Functional assays showed that forced expression of miR-137 in PTC cells significantly inhibited proliferation, colony formation, migration and invasion in vitro. Importantly, on the basis of bioinformatic analysis and luciferase reporter assay, we found that miR-137 directly targeted the 3'-untranslated region (3'-UTR) of C-X-C motif chemokine 12 (also known as SDF-1) (CXCL12). qRT-PCR and western blot analysis further verified the results and demonstrated that miR-137 could downregulate CXCL12 expression in PTC cells. We ...Continue Reading


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Related Concepts

Stem cell-derived factor-1, human
Nonmedullary Thyroid Carcinoma
MIRN137 microRNA, human
Neoplasm Metastasis
Thyroid Gland Follicular Adenoma
Receptor Down-Regulation
Gene Expression Regulation, Neoplastic
3' Untranslated Regions
RNA, Small Temporal

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