MiR-137 acts as a tumor suppressor in papillary thyroid carcinoma by targeting CXCL12

Oncology Reports
Su DongJia Liu

Abstract

Accumulating evidence has shown that aberrantly expressed microRNAs (miRs) are extensively involved in tumorigenesis. microRNA-137 (miR-137) has been reported as a tumor suppressor in various types of cancer. However, the biological function and underlying molecular mechanism of miR-137 in papillary thyroid carcinoma (PTC) remain largely unknown. Therefore, the present study aimed to investigate the expression pattern of miR-137 and its functional significance in PTC. Quantitative RT-PCR (qRT-PCR) assay showed that miR-137 expression was significantly downregulated in human PTC tissues, and its expression was significantly negatively correlated with tumor-node-metastasis (TNM) stage and lymph node metastasis. Functional assays showed that forced expression of miR-137 in PTC cells significantly inhibited proliferation, colony formation, migration and invasion in vitro. Importantly, on the basis of bioinformatic analysis and luciferase reporter assay, we found that miR-137 directly targeted the 3'-untranslated region (3'-UTR) of C-X-C motif chemokine 12 (also known as SDF-1) (CXCL12). qRT-PCR and western blot analysis further verified the results and demonstrated that miR-137 could downregulate CXCL12 expression in PTC cells. We ...Continue Reading

References

Sep 4, 2003·Genome Biology·Julius Brennecke, Stephen M Cohen
Sep 17, 2004·Nature·Victor Ambros
Jun 10, 2005·Nature·Jun LuTodd R Golub
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stefano VoliniaCarlo M Croce
Mar 25, 2006·Nature Reviews. Cancer·Aurora Esquela-Kerscher, Frank J Slack
Dec 20, 2007·Expert Review of Molecular Diagnostics·Marina N Nikiforova, Yuri E Nikiforov
Feb 26, 2009·Cell·Richard W Carthew, Erik J Sontheimer
May 18, 2010·International Journal of Cancer. Journal International Du Cancer·Ming LiuFeng Bi
Jan 12, 2011·Digestive Diseases and Sciences·Qingjiang ChenXinguang Cao
Apr 22, 2011·Journal of Cancer·Rebecca L BrownEzra Ew Cohen
Dec 25, 2012·The Journal of Clinical Endocrinology and Metabolism·Chen-Kai ChouRue-Tsuan Liu
Feb 13, 2013·International Journal of Cancer. Journal International Du Cancer·Kristina AlthoffJohannes H Schulte
Oct 23, 2013·Biochemical and Biophysical Research Communications·Jinling GuoGe Lou
May 9, 2014·Oncotarget·Emanuela MinnaMaria Grazia Borrello
Oct 18, 2014·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Yu HeShuhua Yang
Dec 24, 2014·PloS One·Makoto KinouchiYouji Miyamoto
Jan 21, 2015·Biochemical and Biophysical Research Communications·Lianyong LiuMingjun Gu
May 9, 2015·Molecular Medicine Reports·Liyu ZhangYanping Wang
Jun 25, 2015·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·Y LvC Fang
Jul 1, 2015·Frontiers in Immunology·Takashi Nagasawa
Sep 10, 2015·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jian ZhangLijia Gu
Sep 29, 2015·Thyroid : Official Journal of the American Thyroid Association·Patricia Aragon HanMartha A Zeiger

Citations

Jun 29, 2016·Molecular Diagnosis & Therapy·Zhenjun DengLi He
Oct 23, 2018·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Yijun TianKenkichi Sugimoto
May 18, 2019·Journal of Cellular Biochemistry·Xiong ChengfengLv Yunxia
Sep 7, 2016·Journal of Experimental & Clinical Cancer Research : CR·Peixin DongNoriaki Sakuragi
Jun 8, 2017·Experimental and Therapeutic Medicine·Qiong FengHui Li
Aug 8, 2020·Cancers·Carolina NylénAnthony R Glover
Oct 19, 2017·International Journal of Genomics·Marilena CelanoStefania Bulotta
Dec 11, 2019·International Journal of Molecular Sciences·Soo Jung LeeYee Soo Chae
Nov 21, 2017·Molecular Medicine Reports·Shichang CuiQidong Sun
Sep 11, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Sudharsan Periyasamy-ThandavanSadanand Fulzele

Related Concepts

Stem cell-derived factor-1, human
Nonmedullary Thyroid Carcinoma
MIRN137 microRNA, human
Carcinomatosis
Neoplasm Metastasis
Thyroid Gland Follicular Adenoma
Receptor Down-Regulation
Gene Expression Regulation, Neoplastic
3' Untranslated Regions
RNA, Small Temporal

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