miR-137 inhibits the proliferation of human non-small cell lung cancer cells by targeting SRC3

Oncology Letters
Ruilin ChenShumei Yang

Abstract

Non-small cell lung cancer (NSCLC) is the most common type of lung cancer. The results of the present study demonstrate that high expression of microRNA (miR)-137 and low expression of steroid receptor coactivator-3 (SRC3) had a significant negative correlation in 40 NSCLC tissue samples. In addition, cell colony formation and proliferation was significantly reduced in miR-137-transfected A549 and NCI-H838 cells compared with scramble-transfected NSCLC cell lines. miR-137 was identified to induce G1/S cell cycle arrest and dysregulate the mRNA expression of cell cycle-associated proteins (proliferating cell nuclear antigen, cyclin E, cyclin A1, cyclin A2 and p21) in NSCLC cells. Notably, miR-137 could significantly suppress SRC3 3' untranslated region (UTR) luciferase-reporter activity, an effect that was not detectable when the putative 3'-UTR target-site was mutated, further clarifying the molecular mechanisms underlying the role of miR-137 in NSCLC. In conclusion, the results of the present study suggest that miR-137 suppresses NSCLC cell proliferation by partially targeting SRC3.

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Citations

Jan 14, 2018·Journal of Cellular Biochemistry·Feng DingQiu Zhao
Jan 20, 2018·Cell Death and Differentiation·Meiying LuoYongfei Yang
Apr 21, 2020·Phytotherapy Research : PTR·Mahsa SalehiHamed Mirzaei
Jun 11, 2020·Journal of Cellular Physiology·Milad AshrafizadehSaeed Samarghandian
Nov 11, 2017·Journal of Cellular Biochemistry·Lin GaoZhiqiang Zhang
Aug 4, 2020·Drug Research·Rabiya AhsanMohd Muzahid
Nov 30, 2018·Journal of Cellular Biochemistry·Jia QiAn-Quan Shang
Oct 22, 2019·Frontiers in Cell and Developmental Biology·Thomas G JohnsonGlen Reid
Apr 29, 2020·International Journal of Molecular Sciences·Miaomiao GaoZhengwei Xie
Jun 19, 2021·Biochemical and Biophysical Research Communications·Koujun ZhuYuan Weng

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