miR-142-3p as a novel biomarker for predicting poor prognosis in renal cell carcinoma patients after surgery

The International Journal of Biological Markers
Xiqi PengYongqing Lai

Abstract

miR-142-3p has proved to be involved in tumorigenesis and the development of renal cell carcinoma. The present study aimed to explore the prognostic value of miR-142-3p. Total RNA was extracted from renal cell carcinoma specimens and the expression level of miR-142-3p was measured. Pearson Chi-square test, Kaplan-Meier analysis, as well as univariate and multivariate regression analysis were performed to determine the correlation between miR-142-3p and the prognosis of renal cell carcinoma patients. Receiver operating characteristic curves were constructed to evaluate the predictive efficiency of miR-142-3p for the prognosis of renal cell carcinoma patients. Data from The Cancer Genome Atlas (TCGA) were utilized to validate our findings. Our results demonstrated that upregulation of miR-142-3p was correlated with shorter overall survival (P=0.002) and was, in the meantime, an independent prognostic factor for renal cell carcinoma patients (P=0.002). The receiver operating characteristic curve combining miR-142-3p expression with tumor stage showed an area under the curve of 0.633 (95% confidence interval 0.563, 0.702). The result of TCGA data was consistent with our findings. Our results suggest miR-142-3p expression is correla...Continue Reading

References

Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Mar 6, 2009·Nature Reviews. Cancer·Milena S NicolosoGeorge A Calin
Mar 10, 2009·Lancet·Brian I RiniBernard Escudier
May 8, 2010·Nature Reviews. Urology·Wong-Ho ChowSusan S Devesa
Jul 17, 2010·European Urology·Börje LjungbergUNKNOWN European Association of Urology Guideline Group
Jul 12, 2011·European Urology·Börje LjungbergLambertus A Kiemeney
Sep 2, 2011·Journal of Surgical Oncology·Rui-Jun LinLi-Yan Xu
Nov 25, 2011·Cancer Biomarkers : Section a of Disease Markers·Paul Cairns
Feb 5, 2013·International Urology and Nephrology·Guihua WangLiqin Zhang
Apr 27, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Wei-Wei ShenGuo-Hui Fu
Mar 7, 2014·OncoTargets and Therapy·Virginie NerichAntoine Thiery-Vuillemin
Jul 19, 2014·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Yao-Qi YangPing Hao
Jan 13, 2015·The American Journal of Pathology·Heba W Z KhellaGeorge M Yousef
May 16, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Boya DengKejun Guo
Jun 10, 2015·British Journal of Cancer·I SummererH Zitzelsberger
Sep 29, 2015·Iranian Journal of Cancer Prevention·Reza GhanbariReza Malekzadeh
Jan 23, 2018·Acta Obstetricia Et Gynecologica Scandinavica·Milosz WilczynskiAndrzej Malinowski
Jan 24, 2018·Biochemical and Biophysical Research Communications·Shengni HuaDehua Wu
Feb 15, 2018·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Soum D LokeshwarVinata B Lokeshwar
Apr 4, 2018·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Zhenxin ZhengXiangfeng Zhang
Apr 27, 2018·Cancer Management and Research·Yi-Yen LeeMing-Teh Chen

❮ Previous
Next ❯

Citations

Aug 14, 2020·Cancers·Gonçalo Outeiro-PinhoCarmen Jerónimo
Feb 19, 2021·Bioscience Reports·Rongqiang LiuYi Shao
Apr 2, 2021·Frontiers in Oncology·Keying ZhangWeijun Qin
Oct 12, 2021·Experimental and Therapeutic Medicine·Feng LiuChenjun Huang

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Software Mentioned

SPSS
TCGA

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.