miR-142-3p is a novel regulator of cell viability and proinflammatory signalling in endometrial stroma cells

Reproductive Biomedicine Online
Christin Susanna KästingschäferMartin Götte

Abstract

Endometriosis is associated with severe pelvic pain and reduced fertility. Recently, it has been linked to a dysregulation of microRNAs (miRNAs), which are post-transcriptional regulators of gene expression. The functional effect of dysregulated miR-142-3p expression in endometrial stroma cells was investigated. An increased expression of miR-142-3p resulted in a significantly reduced expression of steroid sulfatase and interleukin-6-coreceptor gp130 as well as reduced interleukin-6-mediated activation of the STAT3-pathway, suggesting an effect of miR-142-3p both on steroid hormone- and cytokine-mediated signalling events. At the functional level, miR-142-3p overexpression significantly reduced cell viability (P ≤ 0.01). miR-142-3p regulation emerges as a future therapeutic strategy for endometriosis.

References

Apr 25, 2007·Gynecological Endocrinology : the Official Journal of the International Society of Gynecological Endocrinology·Tina SmucTea Lanisnik Rizner
Jul 22, 2009·Reproductive Biology and Endocrinology : RB&E·Annemarie SamalecosBirgit Gellersen

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Citations

Mar 1, 2016·Frontiers in Pharmacology·Tea Lanišnik Rižner
Feb 6, 2019·Biology of Reproduction·Sarah Bjorkman, Hugh S Taylor
Jan 5, 2019·The Journal of Clinical Endocrinology and Metabolism·Victoria NisenblatM Louise Hull
Oct 7, 2016·The Journal of Obstetrics and Gynaecology Research·Atsushi KibaTatsuya Watanabe
Aug 28, 2020·Frontiers in Oncology·Soudeh Ghafouri-FardMohammad Taheri
Apr 27, 2018·Human Reproduction Update·Kavita PanirM Louise Hull
Jan 11, 2019·BioMed Research International·Zhuo-Ying TaoDong-Yuan Cao
Aug 28, 2021·Current Issues in Molecular Biology·Anna ZubrzyckaEwa Brzeziańska-Lasota

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