miR-142-3p is a Potential Therapeutic Target for Sensory Function Recovery of Spinal Cord Injury

Medical Science Monitor : International Medical Journal of Experimental and Clinical Research
Tianyi WangWenhua Li

Abstract

Spinal cord injury (SCI), which is a leading cause of disability in modern society, commonly results from trauma. It has been reported that application of sciatic nerve conditioning injury plays a positive role in repairing the injury of the ascending spinal sensory pathway in laboratory animals. Because of the complexity of SCI and related ethics challenges, sciatic nerve conditioning injury cannot be applied in clinical therapy. Accordingly, it is extremely important to study its mechanism and develop replacement therapy. Based on empirical study and clinical trials, this article suggests that miR-142-3p is the key therapeutic target for repairing sensory function, based on the following evidence. Firstly, studies have reported that endogenous cAMP is the upstream regulator of 3 signal pathways that are partially involved in the mechanisms of sciatic nerve conditioning injury, promoting neurite growth. The regulated miR-142-3p can induce cAMP elevation via adenylyl cyclase 9 (AC9), which is abundant in dorsal root ganglia (DRG). Secondly, compared with gene expression regulation in the injured spinal cord, inhibition of microRNA (miRNA) in DRG is less likely to cause trauma and infection. Thirdly, evidence of miRNAs as biomar...Continue Reading

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Citations

Sep 26, 2020·Journal of Cellular and Molecular Medicine·Xin WangTianyi Wang
Oct 22, 2015·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Chao ZhangVladimir P Chekhonin
May 11, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Yugang LiuYanli Xu
Feb 26, 2020·Molecular Biology Reports·Liang ZhangTianyi Wang
Oct 26, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ying ChenXiaodong Wang
Dec 19, 2020·Translational Neuroscience·Jun ZhengWeijing Liao

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Methods Mentioned

BETA
antisense oligonucleotide

Software Mentioned

TargetScan

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