miR-143 promotes angiogenesis and osteoblast differentiation by targeting HDAC7.

Cell Death & Disease
Renkai WangHao Tang

Abstract

The regulation of bone formation and detailed mechanisms are still largely elusive, and the roles of microRNAs in this process have attracted much attention. Recently, a specific subtype of CD31hiendomucinhi (CD31hiEMCNhi) endothelium has been identified to promote bone formation, together with osteoblast development. However, the role of microRNA143 in the generation of CD31hi EMCNhi endothelium and bone formation remains unknown. In this study, we found that miR-143 was expressed both in osteoblast cells and CD31hiEMCNhi endothelial cells. Serum miR-143 level was negatively correlated with age in humans. Overexpression of miR-143 promoted osteoblast formation and angiogenic effects. Furthermore, CD31hiEmcnhi vessels and osteoblast formation were significantly inhibited in miR-143 knockout mice. Mechanistically, inhibitor HDAC7 was directly targeted by miR-143 and knockdown of HDAC7 was found to rescue the function of miR-143 deficiency. Thus, miR-143 promotes angiogenesis coupling with osteoblast differentiation by targeting HDAC7, which may serve as a potential target in angiogenic and osteogenic diseases.

References

May 16, 2003·Nature·Gerard Karsenty
Jul 26, 2005·Nature Medicine·Takako KogaHiroshi Takayanagi
Feb 9, 2007·Proceedings of the National Academy of Sciences of the United States of America·Ximeng LiuThomas L Clemens
Nov 14, 2007·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Eric D JensenJennifer J Westendorf
Jan 24, 2009·Nature Reviews. Molecular Cell Biology·V Narry KimMikiko C Siomi
May 19, 2009·Nature Medicine·Jia ChangCun-Yu Wang
Jul 15, 2009·The Journal of Immunology : Official Journal of the American Association of Immunologists·Jin HouXuetao Cao
Mar 13, 2010·Circulation Research·Andriana MargaritiLingfang Zeng
Mar 23, 2010·Cancer Chemotherapy and Pharmacology·Luke A WittenburgDouglas H Thamm
Jun 17, 2010·The Journal of Biological Chemistry·Kristina KapinasAnne M Delany
Apr 28, 2011·The EMBO Journal·Alejandro P UgaldeCarlos López-Otín
Oct 7, 2011·Journal of Cellular Biochemistry·Luke A WittenburgDouglas H Thamm
Dec 4, 2012·Molecular Endocrinology·Zixue JinYihong Wan
Jul 3, 2013·Nature Reviews. Genetics·Kailiang Sun, Eric C Lai
Nov 16, 2013·Nature Reviews. Drug Discovery·Jonas W HøjfeldtKristian Helin
Mar 13, 2014·Annals of Oncology : Official Journal of the European Society for Medical Oncology·P A CassierD Olmos
Mar 22, 2014·Nature·Saravana K RamasamyRalf H Adams
Nov 7, 2014·Nature Medicine·Anjali P Kusumbe, Ralf H Adams
Nov 13, 2014·The Journal of Biological Chemistry·Elizabeth W BradleyJennifer J Westendorf
Mar 10, 2015·The Journal of Clinical Investigation·Chang-Jun LiXiang-Hang Luo
Sep 18, 2015·Physiological Reviews·Elizabeth W BradleyJennifer J Westendorf
Feb 9, 2016·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Takeshi MoriishiToshihisa Komori
Aug 25, 2016·BioMed Research International·Elizabeth E HullKathryn J Leyva
Sep 7, 2018·Nature·Yuki IkebuchiHiroshi Suzuki

❮ Previous
Next ❯

Citations

Jan 12, 2021·Calcified Tissue International·K Kerschan-SchindlP Pietschmann
Jul 27, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Soudeh Ghafouri-FardMohammad Samadian

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR
electrophoresis
Assay
transfection

Software Mentioned

NRecon
TargetScan
Pro Plus
μCTVol
miRanda
plot
DESeq2
Image
FlowJo
DESeq

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.