miR-145 promoted anoikis resistance in tumor endothelial cells

Journal of Biochemistry
Kyoko HidaYasuhiro Hida

Abstract

Tumor progression is dependent on tumor angiogenesis. We previously reported that the phenotype of tumor endothelial cells (TECs) is distinct from normal endothelial cells (NECs). Herein, we conducted a pathway analysis using a public TEC microarray database and identified several putative TEC-specific miRNAs. We found that miR-145 expression was upregulated in TECs and that miR-145 enhanced cell adhesion and anoikis resistance and upregulated Bcl-2 and Bcl-xl via ERK1/2 in human microvascular endothelial cells. These findings suggested that miR-145 is involved in the acquisition of the TEC phenotype, partially. Therefore, miR-145 and its target genes may be molecular targets for anti-angiogenic therapy.

References

Mar 23, 2010·Biochemical and Biophysical Research Communications·Kohei MatsudaKyoko Hida
Apr 25, 2012·Cancer Metastasis Reviews·Katharine L SodekMaurice J Ringuette
Jul 9, 2013·Biochimica Et Biophysica Acta·Paolo PaoliPaola Chiarugi
Sep 5, 2013·Journal of Molecular and Cellular Cardiology·Yao-Sheng WangRen-Ke Li
Nov 12, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Sukrutha ChettimadaSachin A Gupte

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Citations

May 8, 2020·International Journal of Molecular Sciences·Dorcas Akuba-Muhyia AnnanKyoko Hida

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