miR-149 regulates the proliferation and apoptosis of cervical cancer cells by targeting GIT1

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Bing QianRong Shen

Abstract

MiRNAs are emerging as critical regulators in carcinogenesis and tumor progression. Recently, miR-149 has been demonstrated as a tumor suppressor in several cancers, but its functions in the context of cervical cancer remains unknown. The objective of this study is to investigate the clinicopathological and prognostic values of miR-149 expression and its roles in cervical cancer progression. In this study, miR-149 expression is decreased in CC tissues and cell lines compare with paired normal tissues and normal epithelial cell, respectively. Moreover, the restoration of miR-149 expression inhibited cell proliferation, migration, invasion and promoted cell apoptosis in vitro. We further proved that miR-149 overexpression suppresse the growth of cervical cancer cells in vivo using a mouse xenograft model. Dual luciferase assays identified the GIT1 as a novel direct target of miR-149. To identify the mechanisms, we investigated the PI3K/AKT/mTOR pathway and found that the expression of PI3K, AKT and mTOR were suppressed in cells which were transfected with miR-149 mimics. Taken together, these results indicate that miR-149 is involved in the carcinogenesis and development of cervical cancer by targeting GIT1 via PI3K/AKT/mTOR path...Continue Reading

References

Apr 7, 2006·Journal of Cell Science·Ryan J Hoefen, Bradford C Berk
Jan 13, 2009·Journal of Molecular Biology·Oliver Schlenker, Katrin Rittinger
Nov 4, 2009·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marilena V Iorio, Carlo M Croce
Dec 2, 2009·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Richard HummelJoerg Haier
Mar 18, 2010·Cancer Research·Song-Tao YuDian-Chun Fang
Oct 8, 2011·Omics : a Journal of Integrative Biology·Dan LiGui-Yuan Li
May 26, 2012·Seminars in Cancer Biology·Jonas Fuxe, Mikael C I Karlsson
Jun 2, 2012·Frontiers in Bioscience (Landmark Edition)·Nagaraj S Nagathihalli, Nipun B Merchant
Dec 4, 2012·Arteriosclerosis, Thrombosis, and Vascular Biology·Young Joo JeonNam Keun Kim
Jan 10, 2013·International Journal of Immunopathology and Pharmacology·S-J PanB-M Sun
Jun 4, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Ashok Kumar Pandurangan
Feb 1, 2014·Nature Reviews. Drug Discovery·David A Fruman, Christian Rommel
Apr 1, 2014·Current Opinion in Cell Biology·Petronila PenelaFederico Mayor
May 14, 2014·International Journal of Oncology·Kyung Hee JungSoon-Sun Hong
Jun 6, 2014·Annals of Medicine·Miriam MartiniEmilio Hirsch
Jul 19, 2014·Cancer Research·Annabell BischoffMonilola A Olayioye
Dec 3, 2014·Cancer Letters·Brian ChanShree Ram Singh
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal

❮ Previous
Next ❯

Citations

Apr 9, 2019·Epigenetics : Official Journal of the DNA Methylation Society·Iris BabionRenske D M Steenbergen
Jan 26, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Soudeh Ghafouri-FardMohammad Taheri

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.