MiR-153 regulates expression of hypoxia-inducible factor-1α in refractory epilepsy

Oncotarget
Guo-Hua GongCheng-Xi Wei

Abstract

Mesial temporal lobe epilepsy (mTLE), the most common type of temporal lobe epilepsy (TLE), is particularly relevant due to its high frequency of therapeutic resistance of anti-epileptic therapies. MicroRNAs (miRNAs) have been shown to be dysregulated in epilepsy and neurodegenerative diseases, and we hypothesized that miRNAs could be involved in the pathogenesis of MTLE. The present study aimed to explore the expression and functions of miRNA-153 in mTLE. The expression levels of miRNA-153 in refractory TLE patients were evaluated. The bioinformatics analysis showed that the potential target genes of miR-153 were involved in biological processes, molecular functions, and cellular components. miRNA-153 is significantly dysregulated in temporal cortex and plasma of mTLE patients. We identify HIF-1α as a direct target of miRNA-153, and luciferase reporter assays demonstrated that miR-153 could regulate the HIF-1αexpression via 3'-UTR pairing. These data suggest that miR-153 might represent a useful biomarker and treatment target for patients with mTLE.

References

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Citations

Apr 2, 2019·Thyroid : Official Journal of the American Thyroid Association·Lauren Jin Suk JooStan B Sidhu
Jan 4, 2021·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Ali A Asadi-PooyaAmir Savardashtaki
Apr 4, 2021·Cancer Science·Yao Luo, Ceshi Chen

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Methods Mentioned

BETA
transfections
PCR
transfection

Software Mentioned

SPSS
Gnumeric
geNorm
ImageJ
qbase

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