miR-17-5p as a novel prognostic marker for hepatocellular carcinoma

Journal of Investigative Surgery : the Official Journal of the Academy of Surgical Research
Ling ChenHuihuan Tang

Abstract

miRNAs are frequently deregulated in cancer and have shown promise as tissue-based markers for cancer classification and prognostication. Emerging evidence indicates that miR-17-5p plays an important role in carcinogenesis. However, the expression of miR-17-5p in HCC tissues and its clinical relevance has not been systematically studied yet, and whether miR-17-5p expression has influence on prognosis of HCC is still unknown. In this study, we investigate the expression and clinical significance of miR-17-5p in human HCC. The expression levels of miR-17-5p were measured in 120 paired hepatocellular carcinoma (HCC) and paracarcinomatous liver tissues (PCLTs) derived from patients who underwent hepatic resection by qRT-PCR. Furthermore, the correlation of miR-17-5p levels with clinicopathologic variables and prognosis was analyzed. miR-17-5p was significantly upregulated in HCCs (p < .001). Furthermore, HCC with metastasis had higher miR-17-5p levels than that without metastasis (p < .001). Importantly, the elevated expression of miR-17-5p correlated with multiple tumor nodules (p = .046), worse Edmondson-Steiner grade (p = .024), vein invasion (p = .001), shortened overall survival (p = .012), and disease-free survival (p = .011)...Continue Reading

References

Mar 17, 1999·Annals of Surgery·S T FanJ Wong
Feb 20, 2004·Proceedings of the National Academy of Sciences of the United States of America·George Adrian CalinCarlo M Croce
Jun 24, 2004·Nature Reviews. Genetics·Lin He, Gregory J Hannon
Mar 12, 2005·CA: a Cancer Journal for Clinicians·D Max ParkinPaola Pisani
Jun 10, 2005·Nature·Lin HeScott M Hammond
Oct 28, 2005·The New England Journal of Medicine·George Adrian CalinCarlo M Croce
Aug 1, 2006·Nature Genetics·Michael DewsAndrei Thomas-Tikhonenko
Aug 31, 2006·Molecular and Cellular Biology·Anwar HossainGrady F Saunders
Feb 28, 2008·The Cancer Journal·Muller FabbriGeorge A Calin
Apr 24, 2008·Cancer Science·Shu TakakuraShunichi Yamashita
Jul 30, 2008·Proceedings of the National Academy of Sciences of the United States of America·Patrick S MitchellMuneesh Tewari
Dec 31, 2009·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Yujuan XiongShi-Mei Zhuang
Jan 14, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Maria Teresa LandiEna Wang
Mar 9, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Fu YangShuhan Sun
Mar 12, 2010·Clinical Science·Yunhui ChengChunxiang Zhang
Mar 18, 2010·British Journal of Cancer·M TsujiuraE Otsuji
May 28, 2010·Breast Cancer Research and Treatment·Hongling LiRobert Chunhua Zhao

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Citations

Dec 25, 2012·Medical Oncology·Qun ChenLin Wang
Feb 23, 2013·TheScientificWorldJournal·Jie SunHongchuan Jin
Sep 12, 2013·World Journal of Gastroenterology : WJG·Sharad KhareJamal A Ibdah
May 15, 2013·Chinese Journal of Cancer·Stella Chai, Stephanie Ma
Jan 8, 2014·Theranostics·Thillai V SekarRamasamy Paulmurugan
May 31, 2014·World Journal of Gastroenterology : WJG·Weiqi TanTheresa M C Tan
Feb 27, 2014·Virchows Archiv : an International Journal of Pathology·Mónika GyugosAndrás Kiss
Jan 20, 2016·Journal of Cellular and Molecular Medicine·Yongjie ZhouYujun Shi
Feb 24, 2015·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Sinhwa BaekSimon Weonsang Ro
Jul 22, 2014·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Asahiro Morishita, Tsutomu Masaki
Mar 10, 2015·Clinics and Research in Hepatology and Gastroenterology·Song HeCheng Wei
Mar 29, 2014·Frontiers in Microbiology·Rafael Valencia-QuintanaFrancisco Arenas-Huertero
May 9, 2014·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Benedek GyöngyösiAndrás Kiss
Jun 12, 2018·Journal of Pediatric Hematology/oncology·Çiğdem Ö EcevitNur Olgun
Oct 4, 2018·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Hao ZhangLingyi Kong
Oct 21, 2017·Oncotarget·Madhusudhan Reddy BobbiliHanna Dellago
Jul 4, 2015·World Journal of Hepatology·Magdy Hamed Attwa, Shahira Aly El-Etreby
Apr 23, 2013·International Journal of Molecular Medicine·Jianjian ZhengFujun Yu
Dec 12, 2018·Journal of Cellular Physiology·Javid Sadri NahandHossein Keyvani
Sep 14, 2016·World Journal of Hepatology·Danira Ashraf HabashyAhmed Ihab Abdelaziz
Feb 13, 2021·Cancers·Asahiro MorishitaTsutomu Masaki
Oct 21, 2020·Biomedical Journal·Po-Shuan HuangKwang-Huei Lin

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