miR-17-92 cluster is connected with disease progression and oxaliplatin/capecitabine chemotherapy efficacy in advanced gastric cancer patients: A preliminary study.

Medicine
Baohua FanYushuang Luo

Abstract

This study aimed to determine the role of plasma miR-17-92 cluster level in predicting chemoresistance in patients with gastric cancer (GC) undergoing oxaliplatin/capecitabine (XELOX) chemotherapy.Patients recently diagnosed with advanced GC were chosen as participants based on the inclusion criteria. The plasma levels of miR-17-5p, miR-18a, miR-19a/b, miR-20a, and miR-92-1 (miR-17-92 cluster) were determined through quantitative RT-PCR of blood samples from GC patients and healthy volunteers. All the patients received XELOX chemotherapy, and the effectiveness of the chemotherapy was evaluated.The miR-17-92 plasma level was increased in advanced GC patients and decreased after XELOX chemotherapy. Moreover, the miR-17-92 cluster level was associated with chemotherapy response but not with chemotherapy-related toxicity. The miR-17-92 cluster plasma level was decreased in chemosensitive patients, but not in chemoresistant patients, after chemotherapy. The sensitivity and specificity of the combined detection of the miR-17-92 cluster in patients with advanced GC were 100% each.The results suggest that the miR-17-92 plasma level is associated with the progression of advanced GC and effectiveness of XELOX chemotherapy.

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Citations

May 8, 2020·International Journal of Molecular Sciences·Susana Carregal-RomeroJesús Ruíz-Cabello
Mar 21, 2020·Molecular Cancer·Ling WeiMing Yang
Mar 7, 2021·Biology·Martina GiuppiMichele Ghidini
Oct 15, 2021·Cellular and Molecular Life Sciences : CMLS·Clara Boces-PascualSandra Pérez-Torras

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Methods Mentioned

BETA
contraception
PCR

Software Mentioned

SPSS
GeneGlobe
ABI 7300 SDS

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