miR-17-92 functions as an oncogene and modulates NF-κB signaling by targeting TRAF3 in MGC-803 human gastric cancer cells.

International Journal of Oncology
Fei LiuWeichang Chen

Abstract

The miR-17-92 cluster plays either an oncogenic or anti-oncogenic role in cancer progression in diverse human cancers. However, the underlying mechanisms of the miR-17-92 cluster in gastric cancer have not yet been fully elucidated. In this study, the function of the miR-17-92 cluster in diverse aspects of MGC-803 gastric cancer cells was systematically elucidated. The enforced introduction of the miR-17-92 cluster into the MGC-803 cells significantly promoted cell growth due to the increased cellular proliferation and decreased cellular apoptosis, which were detected by CCK-8, cell viability and TUNEL assays. Moreover, the results of western blot analyses revealed that the activated protein kinase B (AKT), extracellular-signal-regulated kinase (ERK) and nuclear factor (NF-κB) signaling pathways were activated in these processes. Moreover, the overexpression of the miR-17-92 cluster markedly enhanced the migratory and invasive abilities of the MGC-803 cells, which was associated with the occurrence of epithelial-mesenchymal transition (EMT). Tumor necrosis factor receptor associated factor 3 (TRAF3), which negatively regulates the NF-κB signaling pathway, was identified as a direct target of miR-17-92. Furthermore, TRAF3 silenc...Continue Reading

References

Jun 10, 2005·Nature·Lin HeScott M Hammond
Mar 25, 2006·Nature Reviews. Cancer·Aurora Esquela-Kerscher, Frank J Slack
Jul 18, 2007·Advances in Experimental Medicine and Biology·Jeannie Q HeGenhong Cheng
Dec 1, 2009·Cell·Jean Paul ThieryM Angela Nieto
Dec 22, 2009·The Journal of Urology·Tsz-Fung F ChowGeorge M Yousef
May 19, 2011·Cancer Research·Thalia A FaraziThomas Tuschl
Nov 9, 2011·Journal of Surgical Oncology·Ge YuYuan-Lian Wan
Feb 18, 2012·Nature·Amaia Lujambio, Scott W Lowe
Apr 23, 2013·Biochemical and Biophysical Research Communications·Fang WangDaiming Fan
Sep 18, 2013·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Jingjing XuFeng Guo
Mar 15, 2014·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Masahiro TsujiuraEigo Otsuji
Sep 19, 2014·Nature Communications·Melanie L YarbroughBeatriz M A Fontoura
Dec 18, 2014·Toxicological Sciences : an Official Journal of the Society of Toxicology·Hui GuPeixin Yang
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Jun 23, 2015·Laboratory Investigation; a Journal of Technical Methods and Pathology·Jing LiDong Xiao
Aug 4, 2015·Carcinogenesis·Hanqing ZhuTong Wu
Jan 23, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Chuanli RenMing Shen
Jun 21, 2016·International Journal of Molecular Sciences·Ming-Ming TsaiKwang-Huei Lin
Jul 1, 2016·Molecular Medicine Reports·Jinzi ZhouXiaobo Xia
Aug 29, 2016·Molecular and Cellular Endocrinology·Yaxi ChenXijie Yu
Nov 11, 2016·Leukemia & Lymphoma·Xiaoying ZhangXiaofang Wang
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.