miR-183 induces cell proliferation, migration, and invasion by regulating PDCD4 expression in the SW1990 pancreatic cancer cell line

Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie
Ying-Ying LuYue Zeng

Abstract

The aim of this study was to investigate the function of miR-183 in the SW1990 cancer cell line, and the mechanisms regulating these processes. miRNAs are known to play important roles in cancer cell development. However, the pattern and biological role of miR-183 in pancreatic cancer remain largely unknown. Here, we have reported the reduction in pancreatic cancer cell growth in vitro by miR-183 intervention, by inducing apoptosis and decreasing the Bcl-2 expression. Moreover, miR-183 was observed to enhance pancreatic cancer cell migration and invasion, whereas inhibition of miR-183 caused an opposite effect. miR-183 inhibition was shown to increase E-cadherin expression and decrease N-cadherin expression. These regulatory actions play an important role in the cancer epithelial-mesenchymal transition (EMT). Mechanistically, we demonstrated that the overexpression of miR-183 decreased the expression of PDCD4 (programmed cell death 4) mRNA and protein, and vice versa. This helped to identify PDCD4 as the target genes in pancreatic cancer. In conclusion, our analyses indicated miR-183 to be an important contributor to cell migration. This could also be used as a potential therapeutic target for pancreatic cancer treatment.

References

May 11, 2005·World Journal of Gastroenterology : WJG·Hai-Xia QinYong-Chang Wei
Mar 25, 2006·Nature Reviews. Cancer·Aurora Esquela-Kerscher, Frank J Slack
Jan 11, 2008·Evolution & Development·Marsha L PierceGarrett A Soukup
Feb 26, 2008·Cancer Research·Tobias SchmidNancy H Colburn
May 21, 2008·Cytokine & Growth Factor Reviews·Sun-Mi Park, Marcus E Peter
Oct 9, 2008·FEBS Letters·Guofu WangShu Zheng
Nov 29, 2008·BMC Genomics·Harpreet K SainiSam Griffiths-Jones
Mar 17, 2009·International Journal of Oncology·Kazuo MotoyamaMasaki Mori
Apr 10, 2009·Biology of the Cell·Brigitte Lankat-Buttgereit, Rüdiger Göke
Oct 20, 2009·Critical Reviews in Oncology/hematology·Heike Allgayer
Nov 27, 2009·The Journal of Biological Chemistry·Guorong LiPedro Gonzalez
Mar 25, 2010·BMC Cancer·Ulrich LehmannFlorian Länger
Jul 14, 2011·International Journal of Biological Sciences·Shudao XiongYiwei Chu
Nov 25, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Jun YuMichael Goggins
Jul 11, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Gang MaKejian Guo
Nov 14, 2013·TheScientificWorldJournal·Zenghui LiangZhi Du
Nov 28, 2013·Molecular and Cellular Biology·Xiao Ling LiAshish Lal
May 9, 2014·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·F XuB Qian

❮ Previous
Next ❯

Citations

Feb 18, 2016·Cellular and Molecular Neurobiology·Ze-You WangMin-Hui Dai
May 25, 2016·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·Zhennan YeChunhua Hang
Jan 31, 2017·International Journal of Cancer. Journal International Du Cancer·Max M Träger, Sameer A Dhayat
Jun 28, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Muhammad Umar AliCao Jiang
Aug 12, 2018·International Journal of Cancer. Journal International Du Cancer·Anne RiemannOliver Thews
Jul 22, 2019·Scandinavian Journal of Immunology·Xiuzhen LiCongjuan Luo
Jun 16, 2017·Clinical Oral Investigations·Gordana SupicZvonko Magic
Aug 11, 2019·Proceedings of the National Academy of Sciences of the United States of America·Shigeru HashimotoHisataka Sabe
Sep 2, 2016·Frontiers in Molecular Neuroscience·YongPing ChenHui-Fang Shang
Mar 6, 2019·American Journal of Physiology. Endocrinology and Metabolism·Zhen-Zhen ZhangJing Zhang
Nov 21, 2019·Current Molecular Medicine·Wenhui WangJinming Li
Jan 5, 2019·Cancer Metastasis Reviews·Oliver Thews, Anne Riemann
Apr 8, 2021·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·Yi HuangYuju Bai

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

BCL-2 Family Proteins

BLC-2 family proteins are a group that share the same homologous BH domain. They play many different roles including pro-survival signals, mitochondria-mediated apoptosis and removal or damaged cells. They are often regulated by phosphorylation, affecting their catalytic activity. Here is the latest research on BCL-2 family proteins.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Related Papers

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Lei CuiJianxin Zhang
Zhongguo yi xue ke xue yuan xue bao. Acta Academiae Medicinae Sinicae
Gang MaMing Dong
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Sheng LiuGuohui Wan
© 2021 Meta ULC. All rights reserved