Abstract
MicroRNAs (miRNAs) have been demonstrated to be essential regulators in the development and progression of various cancers. The role of miR-188-5p in gastric cancer (GC) has not been determined. In this study, we found that the expression of miR-188-5p was downregulated in GC tissues compared with adjacent normal tissues. The lowly expressed miR-188-5p was significantly associated with lymph node metastasis and advanced TNM stage. Moreover, overexpression of miR-188-5p significantly inhibited GC cell proliferation, migration, and invasion but promoted cellular apoptosis. Mechanistically, we identified transcription factor ZFP91 as a target gene of miR-188-5p in GC. We found that miR-188-5p overexpression significantly inhibited the expression of ZFP91 in GC cell lines. There was an inverse correlation between the expression of miR-188-5p and ZFP91 in GC tissues. We found that restoration of ZFP91 in miR-188-5p-overexpressed MGC-803 and SGC-7901 cells promoted cell proliferation, migration, and invasion. Finally, we also showed that overexpression of miR-188-5p inhibited tumor growth in vivo. Taken together, our findings indicated that miR-188-5p serves as a tumor suppressor in human GC by targeting ZFP91, suggesting that miR-18...Continue Reading
References
Dec 3, 1993·Cell·R C LeeV Ambros
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Mar 13, 2001·International Review of Cytology·H YokozakiE Tahara
Apr 30, 2002·Seminars in Radiation Oncology·Leonard L Gunderson
Jan 28, 2004·Cell·Charles J Sherr
Sep 17, 2004·Nature·Victor Ambros
Jan 18, 2005·Cell·Eugene BerezikovEdwin Cuppen
May 3, 2005·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Wataru YasuiHirofumi Nakayama
Jun 10, 2005·Nature·Jun LuTodd R Golub
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stefano VoliniaCarlo M Croce
May 24, 2006·World Journal of Gastroenterology : WJG·Amy Gallo, Charles Cha
Jun 1, 2006·Nature Genetics·Nikolaus Rajewsky
Oct 31, 2006·Trends in Molecular Medicine·Ramiro GarzonCarlo M Croce
Nov 6, 2007·Frontiers in Bioscience : a Journal and Virtual Library·Marjorie P Perron, Patrick Provost
Feb 1, 2008·The New England Journal of Medicine·Carlo M Croce
Feb 14, 2008·Cell Research·Shuomin ZhuYin-Yuan Mo
Oct 24, 2009·Blood·Ramiro GarzonCarlo M Croce
Mar 8, 2011·Cell·Douglas Hanahan, Robert A Weinberg
May 3, 2011·Current Genomics·Leigh-Ann Macfarlane, Paul R Murphy
May 4, 2013·Gastroenterology Clinics of North America·Pelayo Correa
May 4, 2013·Gastroenterology Clinics of North America·Roopma WadhwaJaffer A Ajani
Nov 26, 2013·Leukemia·S EmmrichM M van den Heuvel-Eibrink
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
Feb 26, 2015·Oncotarget·Hongtuan ZhangYong Xu
May 23, 2015·Journal of Hepatology·Feng FangLian-Yue Yang
May 5, 2016·Oncotarget·Juan MaXuejun Jin
Jan 2, 2018·Cancer Cell·Kie Kyon HuangPatrick Tan
Citations
Mar 29, 2019·Journal of Cellular Biochemistry·Jincai MaShaoling Liu
Apr 23, 2019·Journal of Cellular Biochemistry·Mei WangWenrong Xu
May 8, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Yun-Jiao TianDong-Ju Zhao
Dec 17, 2019·PLoS Pathogens·Huanzhou XuSumita Bhaduri-McIntosh
Oct 28, 2019·Journal of Cellular Physiology·Mei WangWei Zhu
Feb 28, 2020·OncoTargets and Therapy·Zhenming ZhangZhitao Zhang
May 20, 2020·Cell Transplantation·Ping ZhouWeibang Liu
Jul 15, 2020·Journal of Biochemistry·Yuepei ZouShuangming Sun
Sep 13, 2020·IUBMB Life·Kai Yin, Xianzhi Liu
Jun 29, 2018·International Journal of Molecular Sciences·Aelita KonstatinellUgo Moens
Dec 21, 2018·Molecular Medicine Reports·Shuilong ZhangDongliang Wang
Sep 22, 2019·Journal of Cellular Physiology·Xinying ZhuChangwei Qiu
Jan 23, 2019·Acta Biochimica Et Biophysica Sinica·Wenyan ZhuXiaodong Chen
Apr 13, 2019·Cancer Cell International·Jing PeiBenzhong Wang
May 30, 2019·BMC Cancer·Yun LiXu Lin
Nov 13, 2020·Technology in Cancer Research & Treatment·Jinming Zhu, Shichao Han
Nov 26, 2020·The Kaohsiung Journal of Medical Sciences·Xiang-Lu LiXue-Hua Xing
Sep 14, 2019·Molecular Cancer Therapeutics·Zi-Yuan NieJian-Min Luo
Feb 6, 2021·Cancer Chemotherapy and Pharmacology·Xianglan YiSheng Zhou
Oct 23, 2020·Molecular and Cellular Biochemistry·Chengyong WangWeihui Chen
Nov 26, 2020·Cancer Management and Research·Chuanyu ChengZhongjie Shan
Mar 21, 2021·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Tongwu WangHongyu Yang
May 5, 2021·Bioengineered·Hui LiuWei Yang
Jul 11, 2021·Free Radical Biology & Medicine·Jouda GamaraSylvain G Bourgoin
Aug 7, 2021·Technology in Cancer Research & Treatment·Zhenzhao LuoLiqing Wei
Oct 14, 2021·Aging·Yangyang LiuYongbing Chen