miR-188-5p Suppresses Gastric Cancer Cell Proliferation and Invasion via Targeting ZFP91.

Oncology Research
Yuping PengJin Li

Abstract

MicroRNAs (miRNAs) have been demonstrated to be essential regulators in the development and progression of various cancers. The role of miR-188-5p in gastric cancer (GC) has not been determined. In this study, we found that the expression of miR-188-5p was downregulated in GC tissues compared with adjacent normal tissues. The lowly expressed miR-188-5p was significantly associated with lymph node metastasis and advanced TNM stage. Moreover, overexpression of miR-188-5p significantly inhibited GC cell proliferation, migration, and invasion but promoted cellular apoptosis. Mechanistically, we identified transcription factor ZFP91 as a target gene of miR-188-5p in GC. We found that miR-188-5p overexpression significantly inhibited the expression of ZFP91 in GC cell lines. There was an inverse correlation between the expression of miR-188-5p and ZFP91 in GC tissues. We found that restoration of ZFP91 in miR-188-5p-overexpressed MGC-803 and SGC-7901 cells promoted cell proliferation, migration, and invasion. Finally, we also showed that overexpression of miR-188-5p inhibited tumor growth in vivo. Taken together, our findings indicated that miR-188-5p serves as a tumor suppressor in human GC by targeting ZFP91, suggesting that miR-18...Continue Reading

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Citations

Mar 29, 2019·Journal of Cellular Biochemistry·Jincai MaShaoling Liu
May 8, 2019·Artificial Cells, Nanomedicine, and Biotechnology·Yun-Jiao TianDong-Ju Zhao
Feb 28, 2020·OncoTargets and Therapy·Zhenming ZhangZhitao Zhang
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Nov 13, 2020·Technology in Cancer Research & Treatment·Jinming Zhu, Shichao Han
Nov 26, 2020·The Kaohsiung Journal of Medical Sciences·Xiang-Lu LiXue-Hua Xing
Feb 6, 2021·Cancer Chemotherapy and Pharmacology·Xianglan YiSheng Zhou
Nov 26, 2020·Cancer Management and Research·Chuanyu ChengZhongjie Shan
Mar 21, 2021·Journal of Oral Pathology & Medicine : Official Publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology·Tongwu WangHongyu Yang
Jul 11, 2021·Free Radical Biology & Medicine·Jouda GamaraSylvain G Bourgoin

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Datasets Mentioned

BETA
GES-1

Methods Mentioned

BETA
transfection

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