miR-194 inhibits the proliferation, invasion, migration, and enhances the chemosensitivity of non-small cell lung cancer cells by targeting forkhead box A1 protein

Oncotarget
Xuchao ZhuLihong Fan

Abstract

Recent studies have implied that miRNAs may play a crucial role in tumor progression and may be involved in the modulation of some drug resistance in cancer cells. Earlier studies have demonstrated that miR-194 was involved in tumor metastasis and drug resistance in non-small cell lung cancer (NSCLC), whereas their expression and roles on NSCLC still need further elucidation. In the current study, we found that miR-194 is decreased in NSCLC samples compared with adjacent non-cancerous lung samples, and low expression of miR-194 predicts poor patient survival. Both in vitro and in vivo experiments showed that ectopic stable expression miR-194 suppressed proliferation, migration, invasion and metastasis and induced apoptosis in NSCLC cells and that this suppression could be reversed by reintroducing forkhead box A1 (FOXA1), a functional target of miR-194. In addition, miR-194 was downregulated in in cisplatin-resisted human NSCLC cell line-A549/DDP and overexpression of miR-194 increases cisplatin sensitivity. These findings suggested that miR-194 inhibits proliferation and metastasis and reverses cisplatin-resistance of NSCLC cells and may be useful as a new potential therapeutic target for NSCLC.

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Citations

Oct 27, 2017·Cell Death & Disease·Hongzhi DuLi Sun
Oct 28, 2019·Journal of Cellular and Molecular Medicine·Yang GaoPing Wang
Jan 14, 2020·Journal of Cellular Biochemistry·Xian ZhangKai-Run Zhu
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Methods Mentioned

BETA
PCR
flow cytometry
surgical resection
Assay

Software Mentioned

TargetScan
Cell
- QuestTM Pro
SPSS
Image J

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