miR-196B-5P and miR-200B-3P Are Differentially Expressed in Medulloblastomas of Adults and Children.

Michela VisaniAnnalisa Pession


Medulloblastoma is a highly aggressive brain tumor that typically affects children, while in adults it represents ~1% of all brain tumors. Little is known about microRNA expression profile of the rare adult medulloblastoma. The main aim of this study was to identify peculiar differences in microRNA expression between childhood and adult medulloblastoma. Medulloblastomas were profiled for microRNA expression using the Exiqon Human miRNome panel (I + II) analyzing 752 microRNAs in a training set of six adult and six childhood cases. Then, the most differentially expressed microRNAs were validated in a total of 21 adult and 19 childhood cases. Eight microRNAs (miR-196b-5p, miR-183-5p, miR-200b-3p, miR-196a-5p, miR-193a-3p, miR-29c-3p, miR-33b-5p, and miR-200a-3p) were differentially expressed in medulloblastoma of adults and children. Analysis of the validation set confirmed that miR-196b-5p and miR-200b-3p were significantly overexpressed in medulloblastoma of adults as compared with those of children. We followed an in silico approach to investigate direct targets and the pathways involved for the two microRNAs (miR-196b and miR-200b) differently expressed between adult and childhood medulloblastoma. Adult and childhood medullob...Continue Reading


Apr 1, 1990·International Journal of Radiation Oncology, Biology, Physics·H J Bloom, E M Bessell
Nov 1, 1997·Journal of Neuro-oncology·M T GiordanaD Schiffer
Oct 5, 2001·Child's Nervous System : ChNS : Official Journal of the International Society for Pediatric Neurosurgery·C H Rickert, W Paulus
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Oct 3, 2002·Neuro-oncology·Margaret WrenschMitchel S Berger
Oct 8, 2003·International Journal of Radiation Oncology, Biology, Physics·Alba A BrandesFranco Berti
Oct 19, 2004·Neuropathology and Applied Neurobiology·U SchüllerJ Herms
Jan 26, 2006·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Richard J GilbertsonSteven C Clifford
Feb 8, 2006·Proceedings of the National Academy of Sciences of the United States of America·Stefano VoliniaCarlo M Croce
Mar 25, 2006·Nature Reviews. Cancer·Aurora Esquela-Kerscher, Frank J Slack
May 10, 2007·Cancer·Fausto J RodriguezCaterina Giannini
Jun 25, 2008·Nature Reviews. Cancer·Robert G Ramsay, Thomas J Gonda
Jul 9, 2008·Journal of Neuro-oncology·Jessica PiersonRajeev Vibhakar
Jul 24, 2008·Pediatric Blood & Cancer·Celina AngThierry Muanza
Nov 1, 2008·International Journal of Cancer. Journal International Du Cancer·Elisabetta FerrettiAlberto Gulino
Feb 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Tamar UzielMartine F Roussel
Feb 24, 2009·Journal of Neurosurgery·Laurent RiffaudThierry Lesimple
Apr 4, 2009·Acta Neuropathologica·Jesse Chung-sean PangHo-Keung Ng
Oct 23, 2009·Proceedings of the National Academy of Sciences of the United States of America·Edwina McGlinnClifford J Tabin
May 19, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Andrey KorshunovStefan M Pfister
Sep 9, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Paul A NorthcottMichael D Taylor
Oct 6, 2010·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·David W EllisonSteven C Clifford
Nov 26, 2010·Acta Neuropathologica·Hani Al-HalabiNada Jabado
Dec 18, 2010·Science·D Williams ParsonsVictor E Velculescu
Feb 26, 2011·International Journal of Cancer. Journal International Du Cancer·Lei YuFeng Jiang
Mar 2, 2011·Journal of Cancer Research and Therapeutics·Amit GokhaleNeelam Vishwanath Shirsat
Jun 3, 2011·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Marc RemkeAndrey Korshunov
Jun 18, 2011·Acta Neuropathologica·Paul A NorthcottMichael D Taylor
Jul 22, 2011·European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)·Eveline GrunderMichael Grotzer
Jul 29, 2011·Brain Pathology·Sheng-Qing LvHiroko Ohgaki
Dec 3, 2011·Acta Neuropathologica·Michael D TaylorStefan M Pfister
Dec 3, 2011·Acta Neuropathologica·Alfa H C BaiStefan M Pfister
Jun 8, 2012·Journal of Experimental & Clinical Cancer Research : CR·Peng GuanBaosen Zhou
Sep 18, 2012·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Nicolas R Smoll, Katharine J Drummond
Nov 1, 2012·American Journal of Clinical Oncology·Jason A CallNadia N Laack

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