miR-196B-5P and miR-200B-3P Are Differentially Expressed in Medulloblastomas of Adults and Children.

Diagnostics
Michela VisaniAnnalisa Pession

Abstract

Medulloblastoma is a highly aggressive brain tumor that typically affects children, while in adults it represents ~1% of all brain tumors. Little is known about microRNA expression profile of the rare adult medulloblastoma. The main aim of this study was to identify peculiar differences in microRNA expression between childhood and adult medulloblastoma. Medulloblastomas were profiled for microRNA expression using the Exiqon Human miRNome panel (I + II) analyzing 752 microRNAs in a training set of six adult and six childhood cases. Then, the most differentially expressed microRNAs were validated in a total of 21 adult and 19 childhood cases. Eight microRNAs (miR-196b-5p, miR-183-5p, miR-200b-3p, miR-196a-5p, miR-193a-3p, miR-29c-3p, miR-33b-5p, and miR-200a-3p) were differentially expressed in medulloblastoma of adults and children. Analysis of the validation set confirmed that miR-196b-5p and miR-200b-3p were significantly overexpressed in medulloblastoma of adults as compared with those of children. We followed an in silico approach to investigate direct targets and the pathways involved for the two microRNAs (miR-196b and miR-200b) differently expressed between adult and childhood medulloblastoma. Adult and childhood medullob...Continue Reading

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Citations

May 9, 2021·Analytical Biochemistry·Bin WenKui Zhao
Aug 14, 2021·Technology in Cancer Research & Treatment·Wang LiLi Haisha
Sep 21, 2021·Oncology Letters·Ying-Nan ZhaoYa-Wen Pan

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Datasets Mentioned

BETA
GSE49243
GSE41842
GSE21140

Methods Mentioned

BETA
Assay
nuclear translocation
PCR
Profiler

Software Mentioned

GenEx Professional
Profiler
GraphPad Prism
miRnome
GraphPad
CytoHubba
STRING
Enrichr
PANTHER
Geo2R

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