miR-196b is a prognostic factor of human laryngeal squamous cell carcinoma and promotes tumor progression by targeting SOCS2

Biochemical and Biophysical Research Communications
Xudong ZhaoWenyue Ji

Abstract

Laryngeal squamous cell carcinoma (LSCC) has the second highest incidence among the head and neck malignancies. Additionally, the incidence of LSCCs has been recently increasing. Therefore, understanding the mechanisms of LSCC tumorigenesis and identifying novel biomarkers to accurately predict and improve the prognosis of patients with LSCC is extremely important. miR-196b and SOCS2 expression was measured by qRT-PCR and western blot. Their correlation was analyzed with the Pearson test. TU212 and TU177 cells were cultured and transfected for MTT, Transwell, and apoptosis assays upon miR-196b knockdown, SOSC2 overexpression or SOCS2 silencing. Dual-luciferase reporter assay were conducted to identify the relationship between miR-196b and SOCS2. Moreover, the correlation between clinicopathological parameters and miR-196b/SOCS2 expression in patients was analyzed. Univariate and multivariate analysis and log-rank tests were used to determine if miR-196 was an independent LSCC prognostic factors. We reported the aberrant expression and inverse correlation of miR-196b and SOCS2 in LSCC samples. miR-196b promoted LSCC cells proliferation and invasion, and suppressed apoptosis by directly inhibiting SOCS2 expression in vitro. Moreo...Continue Reading

Citations

Jun 16, 2019·Journal of Clinical Medicine·Alice BlossePhilippe Lehours
Nov 8, 2020·Head & Neck·Juliana CarronGustavo J Lourenço
Jan 9, 2021·Anti-cancer Drugs·Liao ChenXuesong Wu
Nov 19, 2020·Heliyon·Soudeh Ghafouri-FardZeinab Shirvani Farsani
Nov 2, 2020·Molecular Biology Reports·Peyman PourdavoudAlireza Shaygannejad
Jun 20, 2021·Critical Reviews in Oncology/hematology·Erison Santana Dos SantosAdriana Franco Paes Leme

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