miR-199a-3p regulates brown adipocyte differentiation through mTOR signaling pathway

Molecular and Cellular Endocrinology
Yao GaoChenBo Ji

Abstract

Recent discoveries of functional brown adipocytes in mammals illuminates their therapeutic potential for combating obesity and its associated diseases. However, on account of the limited amount and activity in adult humans of brown adipocyte depots, identification of miRNAs and characterization their regulatory roles in human brown adipogenesis are urgently needed. This study focused on the role of microRNA (miR)-199a-3p in human brown adipocyte differentiation and thermogenic capacity. A decreased expression pattern of miR-199a-3p was consistently observed during the differentiation course of brown adipocytes in mice and humans. Conversely, its level was induced during the differentiation course of human white pre-adipocytes derived from visceral fat. miR-199a-3p expression was relatively abundant in interscapular BAT (iBAT) and differentially regulated in the activated and aging BAT in mice. Additionally, miR-199a-3p expression level in human brown adipocytes was observed decreased upon thermogenic activation and increased by aging-related stimuli. Using primary pre-adipocytes, miR-199a-3p over-expression was capable of attenuating lipid accumulation and adipogenic gene expression as well as impairing brown adipocytes' metabo...Continue Reading

Citations

Jul 28, 2019·Current Pharmaceutical Biotechnology·Ling ChenJingyun Li
Apr 16, 2019·Current Opinion in Lipidology·Leslie R SedgemanKasey C Vickers
Apr 13, 2020·Mammalian Genome : Official Journal of the International Mammalian Genome Society·Meriem Ouni, Annette Schürmann
Nov 17, 2020·Frontiers in Endocrinology·Yan WangLianghui You
Aug 2, 2020·Molecular and Cellular Endocrinology·Zhuo ZhangXia Chi

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