miR-199b-5p is a regulator of left ventricular remodeling following myocardial infarction

Non-coding RNA Research
Burcu DuyguPaula A da Costa Martins

Abstract

Myocardial infarction (MI), the globally leading cause of heart failure, morbidity and mortality, involves post-MI ventricular remodeling, a complex process including acute injury healing, scar formation and global changes in the surviving myocardium. The molecular mechanisms involved in adverse post-infarct left ventricular remodeling still remain poorly defined. Recently, microRNAs have been implicated in the development and progression of various cardiac diseases as crucial regulators of gene expression. We previously demonstrated that in a murine model of pressure overload, a model of heart failure secondary to aortic stenosis or chronic high blood pressure, elevated myocardial expression of miR-199b-5p is sufficient to activate calcineurin/NFAT signaling, leading to exaggerated cardiac pathological remodeling and dysfunction. Given the differences in left ventricular remodeling secondary to post-infarct healing and pressure overload, we evaluated miR-199b function in post-MI remodeling. We confirmed that the expression of miR-199b is elevated in the post-infarcted heart. Transgenic animals with cardiomyocyte-restricted overexpression of miR-199b-5p displayed exaggerated pathological remodeling after MI, reflected by severe...Continue Reading

Citations

May 8, 2019·Canadian Journal of Physiology and Pharmacology·Jody GroenendykMarek Michalak
Sep 2, 2020·Journal of Tissue Engineering and Regenerative Medicine·Miao ZhangJihong Yan
Aug 23, 2019·International Journal of Molecular Sciences·Carolina Kymie Vasques NonakaMilena Botelho Pereira Soares
Jan 7, 2021·International Journal of Molecular Sciences·Sara PanizoJorge B Cannata-Andía
Mar 24, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Jianxiu WangYingying Nie

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Methods Mentioned

BETA
antisense oligonucleotides
PCR
electrophoresis
fluorescence imaging
transgenic

Software Mentioned

GraphPad
ImageJ
Prism

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