MiR-19a negatively regulated the expression of PTEN and promoted the growth of ovarian cancer cells

Gene
Yuhong WangYanfang Ren

Abstract

Ovarian cancer is the most lethal malignancy of the women genital tract. Exploring novel factors involved in the development of ovarian cancer and characterizing the molecular mechanisms by which regulate the tumorigenesis of ovarian cancer are quite necessary. Here, we found that miR-19a was highly expressed in ovarian cancer tissues and cell lines. Overexpression of miR-19a promoted the viability of ovarian cancer cells, while down-regulation of miR-19a inhibited the growth of ovarian cancer cells. To further understand the underlying molecular mechanism of miR-19a in regulating ovarian cancer cell growth, the downstream targets of miR-19a were predicted. The bioinformatics analysis showed that the tumor suppressor PTEN was found as one of the targeting candidates of miR-19a. MiR-19a bound the 3'-UTR of PTEN and highly expressed miR-19a decreased both the mRNA and protein levels of PTEN in ovarian cancer cells. Overexpression of PTEN suppressed the promoting effect of miR-19a on regulating the growth of ovarian cancer cells. Notably, the expression of miR-19a and PTEN was inversely correlated in ovarian cancer tissues. These results demonstrated the potential oncogenic role of miR-19a in ovarian cancer, which suggested that m...Continue Reading

References

Sep 17, 2004·Nature·Victor Ambros
Oct 3, 2006·Developmental Cell·Wigard P Kloosterman, Ronald H A Plasterk
Sep 19, 2007·Cancer Research·Marilena V IorioCarlo M Croce
Jan 15, 2013·International Journal of Molecular Medicine·Yasuko Kitagishi, Satoru Matsuda
Apr 30, 2013·Asian Pacific Journal of Cancer Prevention : APJCP·Shuang QinWen-Jian Yao
Oct 2, 2013·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Leonardo Vinícius Monteiro de Assis, Mauro César Isoldi
Apr 11, 2014·International Journal of Oncology·Atsuko NakanishiSatoru Matsuda
Apr 29, 2015·World Journal of Gastroenterology : WJG·Wei-Dong LuMin Zhang
Dec 17, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zhen-Hua WuXi-Chun Hu
Feb 15, 2016·Clinical Pharmacology and Therapeutics·F Fanini, M Fabbri
Feb 26, 2016·Methods in Molecular Biology·Bruno Costa GomesAntónio Sebastião Rodrigues
Mar 18, 2016·Journal of Radiation Research·Jennifer Y Y KwanFei-Fei Liu
Mar 26, 2016·The American Journal of Pathology·Robert J Kurman, Ie-Ming Shih
Aug 16, 2016·SpringerPlus·Gonzalo H Giornelli
Oct 25, 2016·Gynecologic Oncology·Anis KaldawySteven A Narod
Sep 9, 2016·Immunotherapy·Soroush AalipourNima Rezaei
Oct 22, 2016·Current Research in Translational Medicine·B IlhanH Karanlik
May 6, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Di ZhaoShaowei Luo
Jun 1, 2017·Bioscience Reports·Qin Zhang, Shuxiang Zhang
Jul 14, 2017·Journal of Cellular Physiology·Bornali DebSupriyo Chakraborty
Oct 20, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Meng HouYue Teng
Nov 21, 2017·Journal of Cellular Physiology·Leyla Norouzi-BaroughRasoul Salehi
Nov 21, 2017·Cell Chemical Biology·Niall M McLoughlinTom N Grossmann

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Citations

Dec 14, 2018·International Journal of Molecular Sciences·Giovanna CalabreseRosalba Parenti
Dec 9, 2020·Critical Reviews in Oncology/hematology·Zahra Sadat RazaviHamed Mirzaei
Mar 23, 2021·In Vitro Cellular & Developmental Biology. Animal·Jinliang MaYongjun Li
May 6, 2021·International Journal of Molecular Sciences·Alessio ArdizzoneIrene Paterniti
Apr 29, 2021·Aging·Srinivasulu Yerukala Sathipati, Shinn-Ying Ho

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