miR-202 Inhibits Cell Proliferation, Migration, and Invasion by Targeting Epidermal Growth Factor Receptor in Human Bladder Cancer.

Oncology Research
Liqing ZhangXiuxia Guo

Abstract

Recent studies have demonstrated that miR-202 is associated with several types of cancer; however, the expression and function of miR-202 have not been investigated in bladder cancer. We analyzed the expression of miR-202 in bladder cancer tissues and adjacent noncancerous tissues. The effect of miR-202 on the proliferation, migration, and invasion was evaluated by in vitro assays. The target gene of miR-202 was assessed by luciferase reporter assay. In this study, miR-202 was found to be significantly downregulated in bladder cancer cell lines and tissues and was highly correlated with the T classification, N classification, grade, and recurrence. Ectopic expression of miR-202 suppressed cell viability, colony formation, cell migration, and invasion in vitro and inhibited xenograft tumor growth in vivo. Inversely, downregulation of miR-202 had contradictory effects. The 3'-untranslated region (3'-UTR) of epidermal growth factor receptor (EGFR) was identified as a direct target of miR-202 using luciferase reporter assays, and knockdown of EGFR enhanced miR-202-inhibited cell proliferation, migration, and invasion. In conclusion, miR-202 suppresses bladder cancer carcinogenesis and progression by targeting EGFR, thereby represen...Continue Reading

Citations

May 7, 2019·Acta Biochimica Et Biophysica Sinica·Yilin LinShaoqin Chen
Oct 12, 2019·Experimental and Therapeutic Medicine·Keqin ZhouWenjie Chen
Jul 3, 2018·Oncology Letters·Shanshan GaoJiancheng Tu
Jul 21, 2019·Molecular Diagnosis & Therapy·Qi LiJunling Shi

Related Concepts

EGFR protein, human
MIRN202 microRNA, human
Metazoa
Malignant Neoplasm of Urinary Bladder
Cell Motility
Mice, Inbred BALB C
Mice, Nude
Neoplasm Invasiveness
Neoplasm Recurrence, Local
Tumor Cells, Cultured

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