PMID: 29764561May 17, 2018Paper

MiR-204 acts as a potential therapeutic target in acute myeloid leukemia by increasing BIRC6-mediated apoptosis

BMB Reports
Zhiguo WangMei Zhang

Abstract

Acute myeloid leukemia (AML) is one of the most common hematological malignancies all around the world. MicroRNAs have been determined to contribute various cancers initiation and progression, including AML. Although microRNA-204 (miR-204) exerts anti-tumor effects in several kinds of cancers, its function in AML remains unknown. In the present study, we assessed miR-204 expression in AML blood samples and cell lines. We also investigated the effects of miR-204 on cellular function of AML cells and the underlying mechanisms of the action of miR-204. Our results showed that miR-204 expression was significantly downregulated in AML tissues and cell lines. In addition, overexpression of miR-204 induced growth inhibition and apoptosis in AML cells, including AML5, HL-60, Kasumi-1 and U937 cells. Cell cycle analysis further confirmed an augmentation in theapoptotic subG1 population by miR-204 overexpression. Mechanistically, baculoviral inhibition of apoptosis protein repeat containing 6 (BIRC6) was identified as a direct target of miR-204. Enforcing miR-204 expression increased the luciferase activity and expression of BIRC6, as well as p53 and Bax expression. Moreover, restoration of BIRC6 reversed the pro-apoptotic effects of miR...Continue Reading

References

Nov 2, 1999·Biochemical and Biophysical Research Communications·Z ChenT Tsuruo
Jun 18, 2004·Molecular Cell·Till BartkeStefan Jentsch
Sep 2, 2004·Nature Cell Biology·Seamus J Martin
Feb 24, 2005·Cancer Biology & Therapy·Zhaoyu Jin, Wafik S El-Deiry
Sep 13, 2006·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Claudia RoldoCarlo M Croce
Sep 6, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Ki Woong SungHong Hoe Koo
Oct 16, 2007·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·D L ZanetteM A Zago
Feb 22, 2011·Biotechnology and Bioengineering·Aliaksandr DruzJoseph Shiloach
Nov 17, 2011·European Journal of Haematology·Eman Abdel Rahman IsmailMahmoud Ahmed Abdelwahab
Mar 27, 2012·Cellular Signalling·Thomas F Reubold, Susanne Eschenburg
Sep 10, 2014·International Journal of Cancer. Journal International Du Cancer·Wenqing TangLing Dong
Oct 9, 2014·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Yuan YinZhaohui Huang
Oct 27, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Tianqi LiRunsheng Li
May 19, 2017·PloS One·Denis O OkumuLee M Graves
Nov 3, 2017·Journal of Cellular Biochemistry·Chun-Jiao SongQian-Nan Ding
Dec 13, 2017·Cancer Research·Marta Díaz-MartínezJoaquin Teixidó
Dec 29, 2017·International Journal of Molecular Sciences·Sirjana ShresthaHsien-Da Huang

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Citations

Aug 29, 2019·Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire·Xueqin SunXiaohui Yu
May 28, 2019·Journal of Hematology & Oncology·Yan LiuLin Fu
Jul 14, 2020·Current Opinion in Oncology·Zhen HanChristiane Querfeld
Feb 13, 2020·International Journal of Laboratory Hematology·Ahmed S AbdelhafizNayera Hamdy

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