MiR-21-5p, miR-34a, and human telomerase RNA component as surrogate markers for cervical cancer progression

Pathology, Research and Practice
Yue ZhuYun-Gui Cao

Abstract

This study aimed to demonstrate the predictive value of miR-21-5p, miR-34a, and human telomerase RNA component (hTERC) in cervical cancer (CC) development and evaluated their potential possibility for future clinical applications. Specimens were collected from the normal cervix, cervical intraepithelial neoplasia (CIN) I, CIN II/III, cervical squamous cell carcinoma. Cytological evaluations and histopathologic examinations were conducted in all subjects, along with the assessment of human papillomavirus (HPV) DNA. The expression levels of the miR-21-5p and miR-34a were detected by RT-PCR. hTERC amplification was detected by dual-color interphase fluorescence in situ hybridization (FISH). Then miRNA, hTERC expressions were compared with the cytological and histologic examination. Compared to that in the benign samples, the expression of miR-21-5p and miR-34a in abnormal samples was significantly upregulated and downregulated, gradually corresponding to the severity of cervical lesions (P < 0.05). There was a trend toward an increasing amplification of hTERC with the increasing severity of cervical lesions. miR-21-5p and miR-34a expression, and hTERC amplification were more specific than HPV positivity in differentiating low-grad...Continue Reading

Citations

Nov 27, 2018·Journal of Cellular Biochemistry·Yitong ZhouLudong Tan
Aug 8, 2019·Cancer Medicine·Xinqi JiaShan Yu
Feb 27, 2020·Journal of Clinical Laboratory Analysis·Haizhen HeLiqin Cao
May 16, 2020·Journal of Cellular and Molecular Medicine·Rao Fu, Jing-Shan Tong
Jun 4, 2019·Frontiers in Oncology·Rafah A A AlnafakhDharani K Hapangama
Mar 21, 2019·Journal of Cellular Physiology·Javid Sadri NahandHamed Mirzaei
May 19, 2021·Journal of Occupational Medicine and Toxicology·Wei LiuJianjun Liu
Aug 14, 2021·Obstetrics & Gynecology Science·Kavitha NagandlaMohamed Faiz Bin Mohamed Jamli
Oct 31, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yunxia AnXueyi Tang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Squamous Cell

Basal cell carcinoma is a form of malignant skin cancer found on the head and neck regions and has low rates of metastasis. Discover the latest research on basal cell carcinoma here.

Related Papers

International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Ying LiXing Xie
International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society
Xiuhui ZhengLi Li
© 2022 Meta ULC. All rights reserved