MiR-215, an activator of the CTNNBIP1/β-catenin pathway, is a marker of poor prognosis in human glioma

Oncotarget
Yong-Qing TongYan Li

Abstract

MicroRNA-215 (miR-215) promotes tumor growth in various human malignancies. However, its role has not yet been determined in human glioma. Here, we found that levels of miR-215 were higher in glioma tissues than in corresponding non-neoplastic brain tissue. High miR-215 expression was correlated with higher World Health Organization (WHO) grades and shorter overall survival. Multivariate and univariate analysis indicated that miR-215 expression was an independent prognostic factor. We also found that TGF-beta1, phosphorylated beta-catenin, alpha-SMA, and fibronectin were increased in glioma tissues. Additionally, CTNNBIP1, a direct target of miR-215, was decreased in glioma compared to adjacent normal tissue. These data indicate that miR-215 activates Wnt/β-catenin signaling by increasing β-catenin phosphorylation, α-SMA expression, and fibronectin expression. It promotes TGF-β1-induced oncogenesis by suppressing CTNNBIP1 in glioma. In summary, miR-215 is overexpressed in human glioma, is involved in TGF-β1-induced oncogenesis, and can be used as a marker of poor prognosis in glioma patients.

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Citations

Jun 3, 2017·Biotechnology Letters·Xiaofeng Meng, Baozhong Shi
Jul 21, 2017·Frontiers in Molecular Neuroscience·Shasha ZhangRenjie Chai
Oct 3, 2018·Journal of Cellular Physiology·Lu HeHongtao Qu
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Jan 19, 2021·Evidence-based Complementary and Alternative Medicine : ECAM·Qiuyue GuoYanqin Huang
Sep 21, 2021·Archives of Gynecology and Obstetrics·Yahong WuXianqing Wu

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Methods Mentioned

BETA
PCR
Assay
protein assay

Software Mentioned

GraphPad Prism
GraphPad

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