miR-223: A Key Regulator in the Innate Immune Response in Asthma and COPD

Frontiers in Medicine
Mirjam P RoffelTania Maes

Abstract

Asthma and Chronic Obstructive Pulmonary Disease (COPD) are chronic obstructive respiratory diseases characterized by airway obstruction, inflammation, and remodeling. Recent findings indicate the importance of microRNAs (miRNAs) in the regulation of pathological processes involved in both diseases. MiRNAs have been implicated in a wide array of biological processes, such as inflammation, cell proliferation, differentiation, and death. MiR-223 is one of the miRNAs that is thought to play a role in obstructive lung disease as altered expression levels have been observed in both asthma and COPD. MiR-223 is a hematopoietic cell-derived miRNA that plays a role in regulation of monocyte-macrophage differentiation, neutrophil recruitment, and pro-inflammatory responses and that can be transferred to non-myeloid cells via extracellular vesicles or lipoproteins. In this translational review, we highlight the role of miR-223 in obstructive respiratory diseases, focusing on expression data in clinical samples of asthma and COPD, in vivo experiments in mouse models and in vitro functional studies. Furthermore, we provide an overview of the mechanisms by which miR-223 regulates gene expression. We specifically focus on immune cell developm...Continue Reading

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Citations

Jan 24, 2021·Cardiovascular Research·Luke B RobertsGraham M Lord
Dec 15, 2020·International Journal of Chronic Obstructive Pulmonary Disease·Yuanyuan WangNianzhi Zhang
Oct 21, 2021·American Journal of Physiology. Lung Cellular and Molecular Physiology·Mirjam P RoffelKen R Bracke
Oct 21, 2020·Biochemical Pharmacology·Joyceline De VolderTania Maes

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Methods Mentioned

BETA
biopsies
bronchoalveolar lavage
ubiquitination
lavage

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