MiR-2392 suppresses metastasis and epithelial-mesenchymal transition by targeting MAML3 and WHSC1 in gastric cancer

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Jinjing LiDaiming Fan

Abstract

MicroRNAs have emerged as essential regulators of various cellular processes. We identified the role and underlying mechanisms of miR-2392 in gastric cancer (GC) metastasis. MiR-2392 was down-regulated in GC cell lines and tissues, and overexpression of miR-2392 significantly inhibited GC invasion and metastasis in vitro and in vivo We identified MAML3 and WHSC1 as novel targets of miR-2392, and knockdown of MAML3 and WHSC1 had the same antimetastatic effect as that of miR-2392 in GC cells. These effects were clinically relevant, as low miR-2392 expression was correlated with high MAML3 and WHSC1 expression and poor survival in patients with GC. Furthermore, forced expression of miR-2392 substantially suppressed Slug and Twist1, transcriptional repressors of E-cadherin, by targeting MAML3 and WHSC1, respectively, resulting in inhibition of the epithelial-mesenchymal transition. These findings indicate that the miR-2392-MAML3/WHSC1-Slug/Twist1 regulatory axis plays a critical role in GC metastasis. Restoration of miR-2392 may be a therapeutic approach for blocking GC metastasis.-Li, J., Li, T., Lu, Y., Shen, G., Guo, H., Wu, J., Lei, C., Du, F., Zhou, F., Zhao, X., Nie, Y., Fan, D. MiR-2392 suppresses metastasis and epithelial-m...Continue Reading

References

Aug 22, 2006·Nature Reviews. Molecular Cell Biology·Sarah J Bray
Feb 14, 2007·Proceedings of the National Academy of Sciences of the United States of America·Vasily VaskoMatthew D Ringel
Mar 29, 2008·Science·Oliver Hobert
Apr 22, 2009·Cell·Raphael Kopan, Maria Xenia G Ilagan
Sep 19, 2009·Nature Reviews. Genetics·Carlo M Croce
Sep 24, 2009·Cancer Research·Douglas R HurstDanny R Welch
Dec 1, 2009·Cell·Jean Paul ThieryM Angela Nieto
Jan 22, 2011·Cancer Cell·Masahiro SonoshitaMakoto Mark Taketo
Mar 10, 2011·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Heidi Rye HudlebuschKristian Helin
Mar 26, 2011·Science·Christine L Chaffer, Robert A Weinberg
Apr 30, 2011·Cancer Research·Heidi Rye HudlebuschKristian Helin
Oct 25, 2011·Oncogene·S-M AhnS Hong
Nov 5, 2011·International Journal of Cancer. Journal International Du Cancer·Xiao Qi WangSheung Tat Fan
Aug 29, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Lin ZhouKaichun Wu
Dec 18, 2013·Cancer Letters·Qiushi LinXiaoqun Dong
Jan 18, 2015·Molecular and Cellular Endocrinology·Ye TianYufeng Dong
Feb 6, 2015·CA: a Cancer Journal for Clinicians·Lindsey A TorreAhmedin Jemal
May 9, 2015·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jun-Nian ZhouXue-Tao Pei
May 10, 2016·Lancet·Eric Van CutsemHans Prenen
Jul 2, 2016·Cell·M Angela NietoJean Paul Thiery

❮ Previous
Next ❯

Citations

Jan 31, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ruifang SunChen Huang
Dec 25, 2019·Signal Transduction and Targeted Therapy·Yuan ChengXiawei Wei
Jul 20, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·F F GolyanM R Abbaszadegan
Jul 6, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Wei FengShaoqing Ju
Dec 17, 2020·Signal Transduction and Targeted Therapy·Yuan ChengXiawei Wei
Jul 22, 2021·Biochemistry. Biokhimii︠a︡·Ekaterina V SeminaKseniya A Rubina
May 15, 2021·Molecular Cancer Research : MCR·Nathaniel AlzofonLauren Fishbein
Oct 9, 2021·Cell Reports·J Tyson McDonaldAfshin Beheshti
Oct 22, 2021·Oncology Letters·Aiko SuetaYutaka Yamamoto

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.