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MiR-24-3p Inhibits the Progression of Pancreatic Ductal Adenocarcinoma Through LAMB3 Downregulation

Frontiers in Oncology

Feb 11, 2020

Wen-Jie HuangYing-Fang Fan

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is associated with several genetic syndromes. However, the molecular mechanism underlying PDAC progression is still unknown. In this study, we showed that Laminin Subunit Beta 3 (LAMB3) was aberrantly overexpressed in PDAC and was closely associat...read more

Mentioned in this Paper

Post-Translational Protein Processing
In Vivo
Pancreatic Ductal Adenocarcinoma
Axis
Cytoplasm
Fluorescent in Situ Hybridization
Down-Regulation
Tumor Model
LAMC2 protein, human
Xenograft Procedure
2
Paper Details
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MiR-24-3p Inhibits the Progression of Pancreatic Ductal Adenocarcinoma Through LAMB3 Downregulation

Frontiers in Oncology

Feb 11, 2020

Wen-Jie HuangYing-Fang Fan

PMID: 32039003

DOI: 10.3389/fonc.2019.01499

Abstract

Pancreatic ductal adenocarcinoma (PDAC) is associated with several genetic syndromes. However, the molecular mechanism underlying PDAC progression is still unknown. In this study, we showed that Laminin Subunit Beta 3 (LAMB3) was aberrantly overexpressed in PDAC and was closely associat...read more

Mentioned in this Paper

Post-Translational Protein Processing
In Vivo
Pancreatic Ductal Adenocarcinoma
Axis
Cytoplasm
Fluorescent in Situ Hybridization
Down-Regulation
Tumor Model
LAMC2 protein, human
Xenograft Procedure
2

Feeds With Similar Papers

Pancreatic Adenocarcinoma

Pancreatic adenocarcinoma holds a significant mortality risk, largely due to its late diagnosis and ineffective chemotherapeutic response. This gastrointestinal malignancy offers a poor prognosis and the only potential cure is through surgical resection. Here are the latest discoveries pertaining to this disease.

MicroRNAs & Open Reading Frames

MicroRNAs are small non-coding RNAs that modulate gene expression at post-transcriptional level, playing a crucial role in cell differentiation and development. Discover the latest research on MicroRNAs & how they target Open Reading Frames.

Related Papers

International Journal of Clinical and Experimental Pathology

MicroRNA-204 attenuates the migration and invasion of pancreatic cancer cells by targeting ZEB1/EMT axis

International Journal of Clinical and Experimental PathologyJuly 1, 2018
Huihan ZhangXiaodong Xu
American Journal of Translational Research

miR-23a-5p inhibits cell proliferation and invasion in pancreatic ductal adenocarcinoma by suppressing ECM1 expression

American Journal of Translational ResearchJune 21, 2019
Wen-Jie HuangHuaizhi Wang
Paper Details
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