MiR-26a contributes to the PDGF-BB-induced phenotypic switch of vascular smooth muscle cells by suppressing Smad1

Oncotarget
Xiaoyan YangYun Zhang

Abstract

The phenotypic switch of vascular smooth muscle cells (VSMCs) is a key event in the pathogenesis of various vascular diseases, such as atherosclerosis and post-angioplasty restenosis. Small non-coding microRNAs (miRNAs) have emerged as critical modulators of VSMC function. In the present study, miR-26a was significantly increased in cultured VSMCs stimulated by platelet-derived growth factor-BB (PDGF-BB) and in arteries with neointimal lesion formation. Moreover, we demonstrated that miR-26a regulates the expression of VSMC differentiation marker genes such as α-smooth muscle actin (α-SMA), calponin and smooth muscle myosin heavy chain (SM-MHC) in PDGF-BB-treated VSMCs. We further confirmed that the regulatory effect of miR-26a during the phenotypic transition occurs through its target gene Smad1, which is a critical mediator of the pro-contractile signal transmitted by bone morphogenetic protein (BMP) and transforming growth factor-beta (TGF-β). This discovery proposed a new channel for communication between PDGF and the BMP/TGF-β family. We concluded that miR-26a is an important regulator in the PDGF-BB-mediated VSMC phenotypic transition by targeting Smad1. Interventions aimed at miR-26a may be promising in treating numerous...Continue Reading

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Citations

May 6, 2020·The FEBS Journal·Eithne Margaret Maguire, Qingzhong Xiao
Sep 1, 2020·Journal of the American Heart Association·Wenqian ZhangDengfeng Gao
Jun 9, 2020·Molecular Biology Reports·Miruna-Mihaela MicheuIon-Andrei Nita
May 16, 2019·PLoS Genetics·Charlene WatterstonSarah J Childs
Apr 2, 2021·Development·Michael Donadon, Massimo M Santoro
Apr 10, 2021·Atherosclerosis·Urna KansakarGaetano Santulli
Apr 14, 2021·Laboratory Investigation; a Journal of Technical Methods and Pathology·Selvaraj VimalrajDhanasekaran Anuradha
Feb 6, 2020·Aging and Disease·Yu-Qing NiYou-Shuo Liu
May 8, 2020·Biochimica Et Biophysica Acta. Molecular Basis of Disease·Guanghong Jia, James R Sowers
Aug 27, 2021·Development·Michael Donadon, Massimo M Santoro

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Methods Mentioned

BETA
PCR
transfection
electrophoresis

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