miR-26a suppresses EMT by disrupting the Lin28B/let-7d axis: potential cross-talks among miRNAs in IPF

Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte
Haihai LiangHongli Shan

Abstract

Idiopathic pulmonary fibrosis (IPF) is a chronic, progressive, and highly lethal fibrotic lung disease with unknown cause or cure. Although some microRNAs (miRNAs), such as miR-26a and let-7d, have been confirmed, the contribution to the pathophysiological processes of IPF, the roles of miRNAs and intrinsic links between them in fibrotic lung diseases are not yet well understood. In this study, we found that Lin28B could induce the process of epithelial-mesenchymal transition (EMT) by inhibiting let-7d, whereas inhibition of Lin28B mitigated TGF-β1-induced fibrogenesis and attenuated EMT in both cultured A549 cells and MLE-12 cells. More importantly, over-expression of miR-26a could simultaneously enhance the expression of let-7d in A549 cells, and further study confirmed that Lin28B was one of the direct targets of miR-26a, which mediates, at least in part, the regulatory effects of miR-26a on the biogenesis of let-7d. Finally, we constructed a regulatory network among miRNAs involved in the progression of IPF. Taken together, our study deciphered the essential role of Lin28B in the pathogenesis of EMT, and unraveled a novel mechanism that miR-26a is a modulator of let-7d. This study also defines the miRNAs network involved in...Continue Reading

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Citations

Apr 24, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xuelian LiHaihai Liang
Jun 29, 2018·American Journal of Physiology. Lung Cellular and Molecular Physiology·Hua JiangHaihai Liang
Jan 16, 2019·Cell Death and Differentiation·Yingzhun ChenHaihai Liang
May 19, 2017·European Respiratory Review : an Official Journal of the European Respiratory Society·Gianluca BagnatoSebastiano Gangemi
Apr 13, 2018·International Journal of Molecular Sciences·Xiaoguang ZhaoHaihai Liang
Mar 18, 2020·Molecular Biology Reports·Yujuan WangJunling Yang
Nov 29, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Hua MiaoYing-Yong Zhao
Jan 8, 2021·Frontiers in Cell and Developmental Biology·Jacopo Di GregorioVincenzo Flati
Jul 7, 2017·Archives of Oral Biology·Ning DongJianping Ruan
Apr 6, 2021·Open Medicine·Hui ZhangZheng Yang
Jun 6, 2021·BMC Pulmonary Medicine·Donato LacedoniaMaria P Foschino-Barbaro

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