miR-27a-3p promotes the malignant phenotypes of osteosarcoma by targeting ten-eleven translocation 1

International Journal of Oncology
Jin LiuJianwei Zhu

Abstract

Osteosarcoma has become one of the most common primary malignant tumors affecting children and adolescents. Although increasing evidence has indicated that microRNAs (miRNAs or miRs) play important roles in the development of osteosarcoma, the expression of miR‑27a‑3p and its effects on osteosarcoma are not yet fully understood. In the present study, our data demonstrated that the expression of miR‑27a‑3p in osteosarcoma cell lines was significantly higher than that in the normal human osteoblastic cell line, hFOB 1.19 cell (P<0.01). In order to explore the role of miR‑27a‑3p in the development and progression of osteosarcoma, the expression of miR‑27a‑3p was inhibited by transfection of the MG-63 cells with miR‑27a‑3p inhibitor. The results revealed that the cell proliferative ability significantly decreased (P<0.01), the number of apoptotic cells significantly increased (P<0.01) and the number of cells passing through the Transwell membrane was significantly reduced in the group transfected with the miR‑27a‑3p inhibitor (P<0.01). At the same time, the expression of E-cadherin and α-catenin was significantly upregulated (P<0.01), while the expression of vimentin was significantly downregulated in the group transfected with the...Continue Reading

References

Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Feb 22, 2014·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Weibo PanZhaoming Ye
Feb 28, 2014·Oncology Reports·Hesong JiangChun-Ping Jiang
Jul 6, 2014·Biomedical Papers of the Medical Faculty of the University Palacký, Olomouc, Czechoslovakia·Sona KollinerovaMartin Modriansky
Sep 2, 2014·Molecular Medicine Reports·Hou-Gen LuGuo-Qing Chen
Dec 15, 2015·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Sumei ZhouXiaohua Zhang
Jan 9, 2016·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·V NatarajS Bakhshi
Jan 23, 2016·Journal of Cellular Physiology·Subbiah RajasekaranRajesh K Thimmulappa
Apr 5, 2016·Journal of Cancer Research and Clinical Oncology·Myrto BamiPanayotis N Soucacos
May 14, 2016·Oncotarget·Liu DingLi Zhihong
Jun 4, 2016·International Immunopharmacology·Sheng-Dong WangZhao-Ming Ye
Jun 21, 2016·Gene·Dan-Dan WangJin-Hai Tang
Jul 2, 2016·Stem Cells International·Ander AbarrategiRene Rodriguez
Oct 23, 2016·Cellular and Molecular Life Sciences : CMLS·Lidong Sun, Jia Fang
Jul 21, 2016·Pediatric Research·Nerea Bilbao-AldaiturriagaAfrica Garcia-Orad
Jul 28, 2016·Journal of Cellular Biochemistry·Christos AdamopoulosAthanasios G Papavassiliou
Jul 30, 2016·Journal of Cancer Research and Clinical Oncology·Andrea AngeliniPietro Ruggieri
Aug 2, 2016·Neurosurgical Focus·Vijay M RavindraDouglas L Brockmeyer
Aug 20, 2016·Clinical Chemistry·Farhana MatinJyotsna Batra
Aug 31, 2016·Advances in Experimental Medicine and Biology·Sippy KaurPäivi Peltomäki
Sep 7, 2016·Cell Chemical Biology·Colleen M ConnellyJohn S Schneekloth
Sep 16, 2016·Anticancer Research·Stephen OsasanConsolato Sergi
Sep 18, 2016·Archives of Gynecology and Obstetrics·Matthias B StopeAlexander Mustea
Sep 21, 2016·Chinese Medical Journal·Cui YangShao-Jun Chen
Sep 28, 2016·Journal of Biotechnology·Franceli Rodrigues KulcheskiRogerio Margis
Sep 28, 2016·World Journal of Gastroenterology : WJG·Kyungjin Lee, Lynnette R Ferguson
Sep 30, 2016·Frontiers in Immunology·Zhan WangZhaoming Ye
Nov 1, 2016·Genes & Development·Deqing Hu, Ali Shilatifard
Jul 25, 2017·Frontiers in Molecular Biosciences·Kecheng ZhouYi Cao

❮ Previous
Next ❯

Citations

Apr 6, 2019·Clinical & Translational Oncology : Official Publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico·G M VieraM S Brassesco
May 21, 2020·Cancer Management and Research·Wei BenYuhui Sun

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Related Papers

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Qingbing MengMinqian Zheng
Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
Qingbing MengMinqian Zheng
© 2022 Meta ULC. All rights reserved